Engineered materials to model human intestinal development and cancer using organoids

Experimental Cell Research
Ricardo Cruz-Acuña, Andrés J García

Abstract

Human organoids provide constructive in vitro models of human development and disease, as these recapitulate important morphogenetic and functional features of the tissue and species of origin. However, organoid culture technologies often involve the use of biologically-derived materials (e.g. Matrigel™) that do not allow dissection of the independent contributions of the biochemical and biophysical matrix properties to organoid development. Additionally, their inherent lot-to-lot variability and, in the case of Matrigel™, tumor-derived nature limits their applicability as platforms for drug and tissue transplantation therapies. Here, we highlight recent studies that overcome these limitations through engineering of novel biomaterial platforms that (1) allow to study the independent contributions of physicochemical matrix properties to organoid development and their potential for translational therapies, and (2) better recreate the tumor microenvironment for high-throughput, pre-clinical drug development. These studies illustrate how innovative biomaterial constructs can contribute to the modeling of human development and disease using organoids, and as platforms for development of organoid-based therapies. Finally, we discuss ...Continue Reading

References

Jul 3, 2002·Nature Reviews. Molecular Cell Biology·Lucy Erin O'BrienKeith E Mostov
Jun 15, 2006·Tissue Engineering·Quynh P PhamAntonios G Mikos
Dec 28, 2006·BMC Medicine·Paolo P ProvenzanoPatricia J Keely
May 22, 2007·Biochemical and Biophysical Research Communications·Angelica M Gutierrez-BarreraShrikanth A G Reddy
Apr 30, 2008·BMC Medicine·Paolo P ProvenzanoPatricia J Keely
Oct 24, 2008·Nature Reviews. Molecular Cell Biology·David M Bryant, Keith E Mostov
Nov 26, 2009·Cell·Kandice R LeventalValerie M Weaver
Feb 18, 2010·Proteomics·Chris S HughesGilles A Lajoie
Jun 11, 2010·Proceedings of the National Academy of Sciences of the United States of America·Jamie L IfkovitsJason A Burdick
Aug 25, 2010·The Journal of Cell Biology·Fei LiuDaniel J Tschumperlin
Sep 9, 2010·Current Opinion in Cell Biology·Mikala EgebladValerie M Weaver
Mar 12, 2011·Advanced Materials·Jason A Burdick, Glenn D Prestwich
Jul 12, 2011·Biomaterials·Bramasta NugrahaHanry Yu
Nov 16, 2011·Nature Protocols·Kyle W McCrackenJason R Spence
Oct 26, 2012·Methods in Molecular Biology·Rana Mroue, Mina J Bissell
Apr 24, 2014·Development·Nikolche GjorevskiMatthias P Lutolf
Sep 4, 2014·Cancer Discovery·Manuel HidalgoAlberto Villanueva
Nov 10, 2014·EMBO Reports·Michael W PickupValerie M Weaver
Jul 18, 2015·Current Opinion in Cell Biology·Andrew G Clark, Danijela Matic Vignjevic
Aug 8, 2015·Molecular Cancer Research : MCR·Andrew GoodspeedJames C Costello
Dec 30, 2015·The Journal of Cell Biology·Nduka O EnemchukwuAndrés J García
Feb 26, 2016·Nature Cell Biology·Aliya FatehullahNick Barker
Jun 18, 2016·Cell·Hans Clevers
Nov 17, 2016·Nature·Nikolce GjorevskiMatthias P Lutolf
Feb 12, 2017·Scientific Reports·Shawn P CareyCynthia A Reinhart-King
Oct 24, 2017·Nature Cell Biology·Ricardo Cruz-AcuñaAndrés J García
Dec 6, 2017·Advanced Healthcare Materials·Pradip Shahi ThakuriHossein Tavana
Jan 5, 2018·Science Translational Medicine·Marsha C Lampi, Cynthia A Reinhart-King
Jan 24, 2018·Biochimica Et Biophysica Acta. Reviews on Cancer·Prakash P PraharajGagan Deep
May 18, 2018·Nature·Christopher M MadlHelen M Blau
Aug 29, 2018·Nature Biomedical Engineering·Holly M PolingMaxime M Mahe
Sep 8, 2018·Nature Protocols·Ricardo Cruz-AcuñaAndrés J García
Jan 18, 2019·Nature·Reiner A WimmerJosef M Penninger

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Citations

Aug 1, 2020·Advanced Biosystems·Panagiota KakniStefan Giselbrecht
Jun 5, 2020·Advanced Healthcare Materials·Jason A Burdick, Andrés J García
Mar 2, 2021·Advanced Science·Barbara Blanco-FernandezJoão F Mano

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