Engineered nanomaterial applications in perinatal therapeutics

Pharmacological Research : the Official Journal of the Italian Pharmacological Society
S B FournierPhoebe A Stapleton

Abstract

Engineered nanomaterials (ENM) are widely used in commercial, domestic, and more recently biomedical applications. While the majority of exposures to ENM are unintentional, biomedical platforms are being evaluated for use in individualized and/or tissue-targeted therapies. Treatments are often avoided during prenatal periods to reduce adverse effects on the developing fetus. The placenta is central to maternal-fetal medicine. Perturbation of placental functions can limit transfer of necessary nutrients, alter production of hormones needed during pregnancy, or allow undesired passage of xenobiotics to the developing fetus. The development of therapeutics to target specific maternal, placental, or fetal tissues would be especially important to reduce or circumvent toxicities. Therefore, this review will discuss the potential use of ENM in perinatal medicine, the applicable physiochemical properties of ENM in therapeutic use, and current methodologies of ENM testing in perinatal medicine, and identify maternal, fetal, and offspring concerns associated with ENM exposure during gestation. As potential nanoparticle-based therapies continue to develop, so does the need for thorough consideration and evaluation for use in perinatal med...Continue Reading

Citations

Jan 1, 2019·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Jeanine N D'Errico, Phoebe A Stapleton
Nov 8, 2019·Pediatric Research·Giovanni Piedimonte, Terri J Harford
Oct 13, 2018·Journal of Nanobiotechnology·Leonie AengenheisterTina Buerki-Thurnherr
Jul 13, 2020·Particle and Fibre Toxicology·Battuja Batbajar DugershawTina Buerki-Thurnherr
Jul 28, 2019·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·J N D'ErricoP A Stapleton
Feb 2, 2021·Science Advances·Rachel S RileyMichael J Mitchell
Jan 24, 2021·Clinical Therapeutics·Nana MatobaJames W Collins
Sep 22, 2020·Advanced Drug Delivery Reviews·Christian G Figueroa-EspadaRachel S Riley
Jul 9, 2021·Environmental Monitoring and Assessment·Kandasamy G MoodleyKrishnan Kanny

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Methods Mentioned

BETA
fluorescence imaging
genetic modifications

Software Mentioned

BeWo

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