Engineered pH-Responsive Mesoporous Carbon Nanoparticles for Drug Delivery.

ACS Applied Materials & Interfaces
Miguel Gisbert-GarzaránMaría Vallet-Regí

Abstract

In this work, two types of mesoporous carbon particles with different morphology, size, and pore structure have been functionalized with a self-immolative polymer sensitive to changes in pH and tested as drug nanocarriers. It is shown that their textural properties allow significantly higher loading capacity compared to typical mesoporous silica nanoparticles. In vial release experiments of a model Ru dye at pH 7.4 and 5 confirm the pH-responsiveness of the hybrid systems, showing that only small amounts of the cargo are released at physiological pH, whereas at slightly acidic pH (e.g., that of lysosomes), self-immolation takes place and a significant amount of the cargo is released. Cytotoxicity studies using human osteosarcoma cells show that the hybrid nanocarriers are not cytotoxic by themselves but induce significant cell growth inhibition when loaded with a chemotherapeutic drug such as doxorubicin. In preparation of an in vivo application, in vial responsiveness of the hybrid system to short-term pH-triggering is confirmed. The consecutive in vivo study shows no substantial cargo release over a period of 96 h under physiological pH conditions. Short-term exposure to acidic pH releases an experimental fluorescent cargo du...Continue Reading

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Citations

May 14, 2020·Nanomaterials·Miguel Gisbert-Garzarán, María Vallet-Regí
Sep 6, 2020·International Journal of Molecular Sciences·Gengqi LiuYumiao Zhang
Dec 4, 2020·Emerging Topics in Life Sciences·Joanna Shepherd
Feb 18, 2021·ACS Applied Materials & Interfaces·Miguel Gisbert-GarzaránMaría Vallet-Regí
Mar 7, 2021·International Journal of Molecular Sciences·Theodora ChristoforidouDimitrios G Fatouros
Nov 14, 2020·Environmental Science and Pollution Research International·Partha RoyGurumurthy Hegde
Dec 24, 2020·International Journal of Molecular Sciences·Miguel Gisbert-GarzaránMaría Vallet-Regí
May 1, 2021·International Journal of Molecular Sciences·Md Motiar RahmanMohamed M Abdel-Daim
May 1, 2021·Materials·Joanna GoscianskaJudyta Cielecka-Piontek
May 6, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Snigdharani PandaSasmita Mohapatra
Jul 3, 2021·Pharmaceutics·Binita ShresthaLiang Tang

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