Engineered repeated electromagnetic field shock therapy for cellular senescence and age-related diseases

Rejuvenation Research
Felipe P PerezDonald A Jurivich

Abstract

A new consensus of gerontologists proposes that delay of biological senescence is the most potent public health measure for preventing chronic disease in late life. At the most fundamental level, cellular aging is characterized by a decline in repair and homeostatic systems. Thus, interventions that protect or rejuvenate these cellular systems hold significant promise for preventing or delaying the onset of age-related diseases. The most likely candidates for delaying senescence are the longevity-linked transcription factors DAF16 and HSF1. If one were to engineer negligible senescence, a key target would be the heat shock protein axis regulated by HSF1. This pathway is the preferred pathway to prevent protein damage or aggregation, whereas DAF-16/FOXO is a backup pathway activated during stress. Reduced HSF1 activity appears to accelerate tissue aging and shortens life span. Conversely, over-expression of HSF1 increases life span and decreases amyloid toxicity in animal models. This paper describes enhancement of the HSR/HSF1 pathway engineered by repeated electromagnetic field shock (REMFS). In a recent study, we demonstrated that REMFS therapy upregulates the HSR/HSF1 pathway, delays cellular senescence in young cells, and t...Continue Reading

References

Feb 28, 1975·Annals of the New York Academy of Sciences·S J Allen
Mar 6, 1992·Science·D A JurivichR I Morimoto
Nov 1, 1991·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·S I Rattan, A Derventzi
May 1, 1990·The Journal of Bone and Joint Surgery. British Volume·W J Sharrard
Aug 1, 1995·Proceedings of the National Academy of Sciences of the United States of America·G J LithgowT E Johnson
Dec 2, 1993·Nature·C KenyonR Tabtiang
Jun 25, 1996·Mechanisms of Ageing and Development·P A Parsons
Oct 1, 1996·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·G J Lithgow
Jan 1, 1997·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·A A KhazaeliJ W Curtsinger
Sep 1, 1997·Journal of Cellular Physiology·L QiuD A Jurivich
Nov 18, 1997·Nature·M TatarJ W Curtsinger
Mar 31, 1998·Environmental Health Perspectives·E J Calabrese, L A Baldwin
Jul 3, 1998·Genes & Development·S H SatyalR I Morimoto
Jul 22, 1998·Cell Stress & Chaperones·R Goodman, M Blank
Nov 25, 1998·Journal of Cellular Biochemistry·L HanR Goodman
Feb 17, 1999·Circulation·A L DiCarloT A Litovitz
Aug 24, 1999·Bioelectromagnetics·J L PipkinD A Casciano
Nov 5, 1999·Biochemical and Biophysical Research Communications·A Michel, H O Gutzeit
Jan 6, 2000·International Journal of Radiation Biology·A L DicarloT A Litovitz
Mar 11, 2000·The Journal of Clinical Investigation·A JoutelE Tournier-Lasserve
Sep 6, 2000·Journal of Cellular Biochemistry·S CarmodyR Goodman
Nov 15, 2000·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·R KurapatiJ Tower
Nov 23, 2000·Nature·L Guarente, C Kenyon
Apr 26, 2001·The Journal of Biological Chemistry·D J Manalo, A Y Liu
May 30, 2001·Current Opinion in Genetics & Development·D Gems, L Partridge
Aug 17, 2001·Human & Experimental Toxicology·S I Rattan
Oct 3, 2001·Physiological Reviews·L H SnoeckxG J Van Der Vusse
Nov 16, 2001·Biogerontology·C Sóti, P Csermely
Feb 19, 2002·Oncogene·Jeremy D HensonRoger R Reddel
Feb 28, 2002·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·James R Cypser, Thomas E Johnson
Jun 7, 2002·Immunity·Wim Van MolleClaude Libert

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Citations

Jan 1, 2010·Rejuvenation Research·Aubrey D N J de Grey
Jan 4, 2020·International Microbiology : the Official Journal of the Spanish Society for Microbiology·Qing LiHong Wu
Mar 3, 2020·Physiological Research·S CrucianiM Maioli
Apr 13, 2021·Archives of Gerontology and Geriatrics·Mohammad Murtaza MehdiPrabhakar Singh

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