Engineered T Regulatory Type 1 Cells for Clinical Application

Frontiers in Immunology
Silvia Gregori, Maria Grazia Roncarolo

Abstract

T regulatory cells, a specialized subset of T cells, are key players in modulating antigen (Ag)-specific immune responses in vivo. Inducible T regulatory type 1 (Tr1) cells are characterized by the co-expression of CD49b and lymphocyte-activation gene 3 (LAG-3) and the ability to secrete IL-10, TGF-β, and granzyme (Gz) B, in the absence of IL-4 and IL-17. The chief mechanisms by which Tr1 cells control immune responses are secretion of IL-10 and TGF-β and killing of myeloid cells via GzB. Tr1 cells, first described in peripheral blood of patients who developed tolerance after HLA-mismatched fetal liver hematopoietic stem cell transplantation, have been proven to modulate inflammatory and effector T cell responses in several immune-mediated diseases. The possibility to generate and expand Tr1 cells in vitro in an Ag-specific manner has led to their clinical use as cell therapy in patients. Clinical grade protocols to generate or to enrich and expand Tr1 cell medicinal products have been established. Proof-of-concept clinical trials with Tr1 cell products have demonstrated the safety and the feasibility of this approach and indicated some clinical benefit. In the present review, we provide an overview on protocols established to ...Continue Reading

References

Nov 11, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Arnaud FoussatHervé Groux
Feb 9, 2006·Seminars in Immunology·Manuela BattagliaMaria-Grazia Roncarolo
Nov 13, 2007·Nature Immunology·Jason S StumhoferChristopher A Hunter
Dec 2, 2008·Clinical and Experimental Immunology·S L ThrowerM Peakman
Jul 25, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Gopal MurugaiyanHoward L Weiner
Jun 15, 2010·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Caroline PotVijay K Kuchroo
Jun 19, 2010·The Journal of Biological Chemistry·Magis MandapathilTheresa L Whiteside
May 9, 2012·Frontiers in Immunology·Silvia GregoriMaria Grazia Roncarolo
Jun 14, 2012·Molecular Therapy : the Journal of the American Society of Gene Therapy·Grazia AndolfiMaria-Grazia Roncarolo
Jan 26, 2013·European Journal of Immunology·Yukiko IwasakiKazuhiko Yamamoto
Mar 1, 2013·Nihon Rinshō Men'eki Gakkai kaishi = Japanese journal of clinical immunology·Yukiko IwasakiKazuhiko Yamamoto
Mar 19, 2013·European Journal of Immunology·Ajithkumar Vasanthakumar, Axel Kallies
Apr 30, 2013·Nature Medicine·Nicola GaglianiMaria-Grazia Roncarolo
May 18, 2013·Nature Reviews. Immunology·Shimon SakaguchiHerman Waldmann
Jul 10, 2013·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·N GaglianiM Battaglia
Feb 20, 2014·Frontiers in Immunology·Rosa BacchettaMaria-Grazia Roncarolo
Jul 10, 2014·Current Topics in Microbiology and Immunology·Maria Grazia RoncaroloManuela Battaglia
Nov 16, 2014·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Klaus G SchmettererWinfried F Pickl
Mar 24, 2015·Neurology. Neuroimmunology and Neuroinflammation·Heather B StreeterDavid C Wraith
May 26, 2015·Nature Medicine·Ivan D MascanfroniFrancisco J Quintana
Dec 5, 2015·Frontiers in Immunology·Silvia GregoriMaria-Grazia Roncarolo
May 20, 2016·Nature Immunology·Ryan NewtonLaurence A Turka
Sep 30, 2016·Frontiers in Immunology·Anna Malgorzata White, David C Wraith
Dec 23, 2016·The Journal of Immunology : Official Journal of the American Association of Immunologists·Leonie BrockmannSamuel Huber
Mar 23, 2017·Proceedings of the National Academy of Sciences of the United States of America·Sofia TousaGeorgina Xanthou
Jun 21, 2017·European Journal of Immunology·Klaus G Schmetterer, Winfried F Pickl
Jun 22, 2017·Nature Communications·Weishan HuangAvery August
Jul 12, 2017·The Journal of Allergy and Clinical Immunology·Laurence PellerinRosa Bacchetta
Jul 25, 2017·Science Immunology·Ping ZhangGeoffrey R Hill
Aug 16, 2017·Molecular Therapy : the Journal of the American Society of Gene Therapy·Grazia LocafaroSilvia Gregori

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Citations

Jan 23, 2019·Journal of Cellular Physiology·Xi JiaJin-An Zhang
Jan 10, 2019·Immunology and Cell Biology·Enwono EyohAnne L Astier
Nov 6, 2018·Annals of the Rheumatic Diseases·Chijioke H Mosanya, John D Isaacs
Mar 22, 2019·EMBO Reports·Mathilde RaverdeauKingston Hg Mills
Apr 16, 2020·Clinical and Experimental Immunology·B MfarrejM Battaglia
Sep 17, 2020·The New England Journal of Medicine·Jeffrey A Bluestone, Mark Anderson
Sep 22, 2019·Nature Reviews. Drug Discovery·Leonardo M R FerreiraQizhi Tang
Oct 12, 2019·ELife·Koshika YadavaPaul L Bollyky
Apr 17, 2020·Frontiers in Immunology·José M CarballidoMichael Kammüller
Nov 12, 2018·Auto- Immunity Highlights·Georgios K VasileiadisGeorgios M Hadjigeorgiou
Feb 26, 2019·Frontiers in Immunology·Marco RomanoGiovanna Lombardi
Mar 25, 2019·Frontiers in Immunology·Govindarajan Thangavelu, Bruce R Blazar
Apr 25, 2020·Bioscience of Microbiota, Food and Health·Tomohiro TakanoSatoshi Hachimura
Dec 5, 2020·European Journal of Immunology·Giulio GigantiCristiano Scottà
Dec 22, 2020·Frontiers in Immunology·Joanna McGintyTony J Kenna
Feb 13, 2021·International Journal of Molecular Sciences·Anaïs AmendNina Chevalier
Jan 22, 2021·Autoimmunity Reviews·Zhussipbek MukhatayevI Caroline Le Poole
Mar 13, 2021·Frontiers in Immunology·Marta FortunatoSilvia Gregori
Mar 16, 2021·Frontiers in Immunology·Leila AminiIgnacio Anegon
Mar 20, 2021·Frontiers in Immunology·Nathaniel OberholtzerSatish N Nadig
Apr 17, 2021·International Immunopharmacology·Huan-Rong LanXue Yang
Jan 12, 2021·Annual Review of Immunology·Geoffrey R HillBruce R Blazar
Jun 29, 2021·Frontiers in Immunology·Ece Canan SayitogluMaria Grazia Roncarolo

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Clinical Trials Mentioned

NCT03198234

Software Mentioned

ONE
Ovasave

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