Engineering a 3D DNA-Logic Gate Nanomachine for Bispecific Recognition and Computing on Target Cell Surfaces

Journal of the American Chemical Society
Ruizi PengWeihong Tan

Abstract

Among the vast number of recognition molecules, DNA aptamers generated from cell-SELEX exhibit unique properties for identifying cell membrane biomarkers, in particular protein receptors on cancer cells. To integrate all recognition and computing modules within a single structure, a three-dimensional (3D) DNA-based logic gate nanomachine was constructed to target overexpressed cancer cell biomarkers with bispecific recognition. Thus, when the Boolean operator "AND" returns a true value, it is followed by an "ON" signal when the specific cell type is presented. Compared with freely dispersed double-stranded DNA (dsDNA)-based molecular circuits, this 3D DNA nanostructure, termed DNA-logic gate triangular prism (TP), showed better identification performance, enabling, in turn, better molecular targeting and fabrication of recognition nanorobotics.

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Citations

Apr 27, 2019·Small·Jinyoung SeoJwa-Min Nam
Mar 13, 2019·Annual Review of Analytical Chemistry·Guoxin RongHeather A Clark
May 8, 2019·Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry·Xiu WangPiaopiao Chen
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Aug 22, 2020·Chemical Communications : Chem Comm·Jiaoli WangKemin Wang
Aug 14, 2019·Chemical Society Reviews·Wenjing WangJun-Jie Zhu
Apr 8, 2020·Nanoscale Horizons : the Home for Rapid Reports of Exceptional Significance in Nanoscience and Nanotechnolgy·Dean HoTheodore Kee
Apr 29, 2020·Research : a Science Partner Journal·Yiting Jiang, Peng Miao
Sep 15, 2020·Science Advances·Sungi KimJwa-Min Nam
May 8, 2019·Chemical Communications : Chem Comm·Xiaowen XuWei Jiang
Feb 8, 2020·Topics in Current Chemistry·Xiaoyi FuXiao-Bing Zhang
Mar 12, 2020·Nature Communications·Naama Lahav-MankovskiDavid Margulies
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Nov 5, 2020·ACS Applied Materials & Interfaces·Meihua LinFan Xia
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May 21, 2021·Journal of Pharmaceutical Analysis·Mirza Muhammad Faran Ashraf BaigJahanzeb Mudassir
Apr 20, 2021·Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry·Hui LvFei Wang

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