Engineering a biological pacemaker: in vivo, in vitro and in silico models.

Drug Discovery Today. Disease Models
Richard B Robinson

Abstract

Several hundred thousand electronic pacemakers are implanted in the US each year to treat abnormally slow heart rates. Biological pacemaker research strives to replace this hardware, and the associated monitoring and maintenance, by using gene or cell therapy to create a permanent and autonomically responsive pacemaker. While there are numerous technological hurdles to overcome before this is a therapeutic reality, one critical issue is determining the optimal channel gene to employ in creating a biological pacemaker. This review discusses the pros and cons of various model systems for characterizing and evaluating the function of candidate channel genes. It is argued that a sequential approach that combines in silico, in vitro and in vivo models is required.

References

Sep 22, 1984·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·D Noble, S J Noble
May 31, 2001·The Journal of General Physiology·C AltomareD DiFrancesco
Sep 13, 2001·Proceedings of the National Academy of Sciences of the United States of America·J ChenM C Sanguinetti
Aug 6, 2002·Trends in Cardiovascular Medicine·Martin BielChristian Wahl
Aug 24, 2002·Pflügers Archiv : European journal of physiology·Jihong QuRichard B Robinson
Sep 13, 2002·Nature·Junichiro MiakeH Bradley Nuss
Mar 5, 2003·Circulation·Jihong QuMichael R Rosen
Feb 10, 2004·The Journal of Physiology·Virginijus ValiunasIra S Cohen
Feb 28, 2004·Circulation Research·Irina PotapovaIra S Cohen
Sep 15, 2004·Cardiovascular Research·Michael R RosenRichard B Robinson
Sep 28, 2004·Nature Biotechnology·Izhak KehatLior Gepstein
Feb 16, 2005·The Journal of General Physiology·Roope MännikköFredrik Elinder
Jun 17, 2006·The Journal of Physiology·Fredrik ElinderH Peter Larsson
Aug 23, 2006·Circulation·Annalisa BucchiMichael R Rosen
Feb 5, 2008·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Alexei N PlotnikovMichael R Rosen
Mar 17, 2009·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Robert G Hauser, David L Hayes
Apr 14, 2009·Journal of Molecular and Cellular Cardiology·Edward G Lakatta, Dario DiFrancesco
Apr 1, 2008·Circulation. Arrhythmia and Electrophysiology·Michael R RosenRichard B Robinson

❮ Previous
Next ❯

Citations

Apr 7, 2012·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Pietro ScicchitanoMarco Matteo Ciccone
Oct 19, 2017·Current Opinion in Cardiology·Derek S Chew, Vikas Kuriachan
Apr 20, 2014·Journal of Cardiovascular Pharmacology and Therapeutics·Gerard J J Boink, Richard B Robinson
Jan 14, 2017·Journal of the American College of Cardiology·Malini MadhavanPaul A Friedman

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiac Regeneration

Cardiac regeneration enables the repair of irreversibly damaged heart tissue using cutting-edge science, including stem cell and cell-free therapy. Discover the latest research on cardiac regeneration here.

Related Papers

Expert Review of Cardiovascular Therapy
Sabine Telemaque, James D Marsh
Circulation. Arrhythmia and Electrophysiology
Michael R RosenRichard B Robinson
Hematology/oncology Clinics of North America
Michael D Tarantino, George R Buchanan
Breast Cancer Research : BCR
Sarah E BurdallValerie Speirs
© 2021 Meta ULC. All rights reserved