Engineering acyl-homoserine lactone-interfering enzymes toward bacterial control.

The Journal of Biological Chemistry
Raphaël BillotDavid Daudé

Abstract

Enzymes able to degrade or modify acyl-homoserine lactones (AHLs) have drawn considerable interest for their ability to interfere with the bacterial communication process referred to as quorum sensing. Many proteobacteria use AHL to coordinate virulence and biofilm formation in a cell density-dependent manner; thus, AHL-interfering enzymes constitute new promising antimicrobial candidates. Among these, lactonases and acylases have been particularly studied. These enzymes have been isolated from various bacterial, archaeal, or eukaryotic organisms and have been evaluated for their ability to control several pathogens. Engineering studies on these enzymes were carried out and successfully modulated their capacity to interact with specific AHL, increase their catalytic activity and stability, or enhance their biotechnological potential. In this review, special attention is paid to the screening, engineering, and applications of AHL-modifying enzymes. Prospects and future opportunities are also discussed with a view to developing potent candidates for bacterial control.

References

Sep 26, 1995·Proceedings of the National Academy of Sciences of the United States of America·M K WinsonB W Bycroft
Apr 27, 2000·Journal of Bacteriology·S L McKnightE C Pesci
Sep 7, 2000·Current Opinion in Biotechnology·M OlsenG Georgiou
Sep 7, 2001·Annual Review of Microbiology·M B Miller, B L Bassler
Oct 13, 2001·Critical Reviews in Microbiology·N Durán, C F Menck
Jan 10, 2002·Journal of Pediatric Surgery·A ChattopadhyayPlng Rao
Nov 27, 2002·Antonie van Leeuwenhoek·Mark H J SturmeWillem M de Vos
May 6, 2003·Bioorganic & Medicinal Chemistry Letters·Kathryn E S DeanJean-Louis Reymond
Jun 12, 2003·The Journal of Infection·H Donabedian
Aug 21, 2003·Trends in Plant Science·Matthew A Escobar, Abhaya M Dandekar
Jan 22, 2004·The Journal of Biological Chemistry·Lian-Hui WangLian-Hui Zhang
Sep 11, 2004·Current Opinion in Biotechnology·Jean-Philippe Goddard, Jean-Louis Reymond
May 24, 2005·Extremophiles : Life Under Extreme Conditions·Luigia MeroneGiuseppe Manco
Oct 11, 2005·Annual Review of Cell and Developmental Biology·Christopher M Waters, Bonnie L Bassler
Oct 29, 2005·FEMS Microbiology Letters·Chang-Sik Oh, Steven V Beer
Feb 21, 2006·International Journal of Medical Microbiology : IJMM·Matthew Walters, Vanessa Sperandio
Feb 24, 2006·Infection and Immunity·Charles F SioWim J Quax
Jul 28, 2006·Letters in Applied Microbiology·B Austin, X-H Zhang
Jan 20, 2007·FEMS Microbiology Letters·Laura Steindler, Vittorio Venturi
Jan 15, 2008·Applied and Environmental Microbiology·Stéphane UrozYves Dessaux
Feb 12, 2008·Microbiological Research·Jieru PanXiong Guan
Apr 22, 2008·Applied and Environmental Microbiology·Tomohiro KawaguchiAlan W Decho
May 20, 2008·Journal of Molecular Biology·Mikael EliasEric Chabriere
Aug 30, 2008·British Medical Bulletin·Roman PopatStephen P Diggle
Dec 17, 2008·Chemical Communications : Chem Comm·Jean-Louis ReymondNoélie Maillard
Jan 31, 2009·IUBMB Life·Hans LeemhuisLubbert Dijkhuizen
Apr 8, 2009·Molecular Plant-microbe Interactions : MPMI·Elise HaudecoeurDenis Faure
Sep 22, 2009·Current Opinion in Structural Biology·Nobuhiko Tokuriki, Dan S Tawfik
Feb 25, 2010·Natural Product Reports·Jeroen S Dickschat
Apr 15, 2010·Biofouling·K V Thomas, S Brooks
May 5, 2010·Cold Spring Harbor Protocols·Stephen T Smale

❮ Previous
Next ❯

Citations

May 12, 2021·Journal of Agricultural and Food Chemistry·Sapir Ya'ar BarLivnat Afriat-Jurnou
Aug 10, 2021·Physiology and Molecular Biology of Plants : an International Journal of Functional Plant Biology·Anamika SaralSameer Suresh Bhagyawant
Sep 4, 2021·NPJ Systems Biology and Applications·Xiang LiJianwei Shuai

❮ Previous
Next ❯

Related Concepts

Related Feeds

ASBMB Publications

The American Society for Biochemistry and Molecular Biology (ASBMB) includes the Journal of Biological Chemistry, Molecular & Cellular Proteomics, and the Journal of Lipid Research. Discover the latest research from ASBMB here.

Biofilms

Biofilms are adherent bacterial communities embedded in a polymer matrix and can cause persistent human infections that are highly resistant to antibiotics. Discover the latest research on Biofilms here.