Engineering an artificial alveolar-capillary membrane: a novel continuously perfused model within microchannels.

Journal of Pediatric Surgery
Divya D NalayandaFizan Abdullah

Abstract

Pulmonary hypoplasia is a condition of the newborn that is characterized by underdeveloped lungs and poor outcome. One strategy in the treatment of patients with hypoplasia is to augment underdeveloped lungs using biocompatible artificial lung tissue. However, one central challenge in current pulmonary tissue engineering efforts remains the development of a stable bio-mimetic alveolar-capillary membrane. Accordingly, we have built a series of bio-mimetic microfluidic devices that specifically model the alveolar-capillary membrane. Current designs include a single-layer microchip that exposes alveolar and endothelial cell types to controlled fluidic stimuli. A more advanced multi-layered device allows for alveolar cells to be cultured at an air interface while allowing constant media nourishment and waste removal, thus better mimicking the physiologic milieu of the alveolar-capillary interface. Both devices possess the benefit of parallel testing. Microdevices were fabricated using soft lithography in a biocompatible transparent polymeric material, polydimethyl siloxane, sealed covalently to glass. The multistage microdevice also integrated a suspended polyethylene terephthalate membrane connected via microfluidic channels to co...Continue Reading

References

Dec 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·S SchürchJ A Clements
Nov 1, 1990·Obstetrical & Gynecological Survey·D M ShererJ R Woods
May 6, 2006·Tissue Engineering·Mark J MondrinosChristine M Finck
Aug 19, 2007·Experimental Lung Research·Divya D NalayandaFizan Abdullah
Jun 2, 2009·Biomedical Microdevices·Divya D NalayandaFizan Abdullah

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Citations

Sep 24, 2010·Journal of the Royal Society, Interface·Cassandra M Kelleher, Joseph P Vacanti
Feb 3, 2012·Respirology : Official Journal of the Asian Pacific Society of Respirology·Hiroshi Kubo
Jan 1, 2012·Scientifica·Sanjeev Kumar MahtoJosué Sznitman
Dec 18, 2013·Biomedical Microdevices·Ludivine BolMyriam Taverna
Aug 8, 2015·International Journal of Molecular Sciences·Amelia Ahmad Khalili, Mohd Ridzuan Ahmad
Jun 1, 2014·Advanced Drug Delivery Reviews·Cristiane de Souza CarvalhoClaus-Michael Lehr
May 16, 2015·Archives of Toxicology·Hedwig M BraakhuisHans Bouwmeester
Sep 5, 2013·Advanced Drug Delivery Reviews·Kae SatoKiichi Sato
Mar 3, 2015·Current Transplantation Reports·Angela Panoskaltsis-Mortari
May 25, 2016·Archives of Toxicology·Monita SharmaAmy J Clippinger
Sep 16, 2018·Annals of Biomedical Engineering·Navein ArumugasaamyJohn P Fisher
Jun 28, 2016·American Journal of Physiology. Lung Cellular and Molecular Physiology·Jurjan AmanVictor W M van Hinsbergh
Nov 16, 2011·Expert Review of Respiratory Medicine·Emily J Swindle, Donna E Davies
Dec 6, 2018·Advanced Healthcare Materials·Vardhman Kumar, Shyni Varghese
Jun 1, 2018·Applied in Vitro Toxicology·Samantha C Faber, Shaun D McCullough
Jun 26, 2014·Experimental Biology and Medicine·Joan E NicholsJoaquin Cortiella
Apr 11, 2016·ACS Biomaterials Science & Engineering·Piyush BajajRashi Iyer

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