Engineering biological gradients

Journal of Applied Biomaterials & Functional Materials
L SardelliP Petrini

Abstract

Biological gradients profoundly influence many cellular activities, such as adhesion, migration, and differentiation, which are the key to biological processes, such as inflammation, remodeling, and tissue regeneration. Thus, engineered structures containing bioinspired gradients can not only support a better understanding of these phenomena, but also guide and improve the current limits of regenerative medicine. In this review, we outline the challenges behind the engineering of devices containing chemical-physical and biomolecular gradients, classifying them according to gradient-making methods and the finalities of the systems. Different manufacturing processes can generate gradients in either in-vitro systems or scaffolds, which are suitable tools for the study of cellular behavior and for regenerative medicine; within these, rapid prototyping techniques may have a huge impact on the controlled production of gradients. The parallel need to develop characterization techniques is addressed, underlining advantages and weaknesses in the analysis of both chemical and physical gradients.

References

Jul 1, 1997·Journal of Biomedical Materials Research·M LampinM F Sigot-Luizard
Jan 1, 1997·Methods in Molecular Biology·D ZichaG Jones
Feb 7, 1998·Proceedings of the National Academy of Sciences of the United States of America·J Zhou, Y C Fung
Jul 25, 1998·FEBS Letters·A Vinckier, G Semenza
Mar 3, 1986·Physical Review Letters·G BinnigC Gerber
Jun 27, 2000·Biophysical Journal·C M LoY L Wang
Mar 12, 2002·Tissue Engineering·William L MurphyDavid J Mooney
Jun 17, 2003·Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine·J S JurvelinE B Hunziker
Jun 18, 2003·The Journal of Cell Biology·Holger GerhardtChrister Betsholtz
Dec 29, 2004·Langmuir : the ACS Journal of Surfaces and Colloids·Jilin ZhangYanchun Han
Mar 17, 2005·Bioconjugate Chemistry·Moon Suk KimHai Bang Lee
Apr 30, 2005·Biomaterials·Vassilis Karageorgiou, David Kaplan
May 26, 2006·Nature·Jacques PouysségurNathalie M Mazure
Jul 28, 2006·Nature·George M Whitesides
Jan 27, 2007·Journal of Biomaterials Applications·Lijun KongXiufang Zhang
May 8, 2007·Progress in Biophysics and Molecular Biology·Miguel Valderrábano
Jun 1, 2007·Lab on a Chip·Shing-Yi ChengMingming Wu
Jun 12, 1992·Science·M K Chaudhury, G M Whitesides
Dec 21, 2007·Lab on a Chip·Thomas M Keenan, Albert Folch
Jan 29, 2008·Langmuir : the ACS Journal of Surfaces and Colloids·Jan Genzer, Rajendra R Bhat
Feb 12, 2008·Nature Reviews. Microbiology·Philip S Stewart, Michael J Franklin
Mar 1, 2008·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Rebecca G Wells
Apr 23, 2008·Annals of Medicine·Sanna M PeltolaMinna Kellomäki
Nov 22, 2008·The Journal of Hospital Infection·C D Owens, K Stoessel
Dec 17, 2008·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Shu-Hua TengHyoun-Ee Kim
Jan 27, 2009·Cell Motility and the Cytoskeleton·Ektoras HadjipanayiRobert A Brown
May 22, 2009·Nature Materials·Elsie S PlaceMolly M Stevens
Jan 15, 2011·Acta Biomaterialia·Azadeh SeidiAli Khademhosseini
Jan 1, 2013·Journal of the Mechanical Behavior of Biomedical Materials·A SaaraiP Saha
Apr 24, 2013·International Journal of Biological Macromolecules·Atif IslamTariq Yasin
Oct 24, 2013·Dalton Transactions : an International Journal of Inorganic Chemistry·Zipeng XingHonggang Fu
Dec 12, 2013·Journal of Biomedical Materials Research. Part a·Beob Soo KimYong Woo Cho
Jan 8, 2014·Biomicrofluidics·Shan-Wen HuHong-Yuan Chen
Jan 31, 2014·International Journal of Molecular Sciences·Hyun Hee AhnMoon Suk Kim
Feb 20, 2014·Advanced Materials·David B KoleskyJennifer A Lewis

❮ Previous
Next ❯

Methods Mentioned

BETA
atomic force microscopy
bioprinting
imaging techniques
bioprinter
scanning electron microscopy
X-ray
infrared spectroscopy
atomic
infrared

Related Concepts

Related Feeds

Adult Stem Cells

Adult stem cells reside in unique niches that provide vital cues for their survival, self-renewal, and differentiation. They hold great promise for use in tissue repair and regeneration as a novel therapeutic strategies. Here is the latest research.

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.

Allogenic & Autologous Therapies

Allogenic therapies are generated in large batches from unrelated donor tissues such as bone marrow. In contrast, autologous therapies are manufactures as a single lot from the patient being treated. Here is the latest research on allogenic and autologous therapies.

Related Papers

Advances in Experimental Medicine and Biology
Bon Kang GuChun-Ho Kim
Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery
Yongxiang LuoMichael Gelinsky
© 2022 Meta ULC. All rights reserved