Engineering CAR T Cells with Biomaterials

Cancer Discovery

Abstract

Incorporating biomaterials into the design of CAR T cells may yield new, improved versions of this immunotherapy. Two preclinical studies indicate the potential of using biodegradable nanoparticles to program circulating T cells into CAR T cellsin situ, and delivering these therapeutic cells directly to solid tumors via small dissolvable sponges.

Citations

Dec 7, 2018·International Journal of Molecular Sciences·Suchithra Poilil SurendranYong Yeon Jeong
Dec 4, 2019·Briefings in Functional Genomics·Ming ChenDi Zhu
Jun 20, 2019·Frontiers in Bioengineering and Biotechnology·Hasan UludagAysha Ansari

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