Engineering cell factories for producing building block chemicals for bio-polymer synthesis

Microbial Cell Factories
Yota TsugeAkihiko Kondo

Abstract

Synthetic polymers are widely used in daily life. Due to increasing environmental concerns related to global warming and the depletion of oil reserves, the development of microbial-based fermentation processes for the production of polymer building block chemicals from renewable resources is desirable to replace current petroleum-based methods. To this end, strains that efficiently produce the target chemicals at high yields and productivity are needed. Recent advances in metabolic engineering have enabled the biosynthesis of polymer compounds at high yield and productivities by governing the carbon flux towards the target chemicals. Using these methods, microbial strains have been engineered to produce monomer chemicals for replacing traditional petroleum-derived aliphatic polymers. These developments also raise the possibility of microbial production of aromatic chemicals for synthesizing high-performance polymers with desirable properties, such as ultraviolet absorbance, high thermal resistance, and mechanical strength. In the present review, we summarize recent progress in metabolic engineering approaches to optimize microbial strains for producing building blocks to synthesize aliphatic and high-performance aromatic polymers.

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Citations

Feb 2, 2017·Microbial Cell Factories·Emma KarlssonLisbeth Olsson
Dec 3, 2016·Journal of Industrial Microbiology & Biotechnology·Xiangmin FuShengde Zhou
Jun 7, 2017·FEMS Yeast Research·Quinten DeparisJohan M Thevelein
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Jan 17, 2019·Bioinformatics·Philipp Schneider, Steffen Klamt
Apr 14, 2020·Biotechnology and Bioengineering·So Young ChoiSang Yup Lee
Nov 19, 2017·Applied Microbiology and Biotechnology·Yukie KawasakiNaoki Takaya
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Apr 23, 2020·Frontiers in Bioengineering and Biotechnology·Luz YañezFelipe Scott
Jan 22, 2019·Frontiers in Bioengineering and Biotechnology·Behrouz Mohammadi NargesiJung-Won Youn
Sep 27, 2018·Current Protein & Peptide Science·Jean-Étienne R L Morlighem, Gandhi Radis-Baptista
Feb 12, 2021·World Journal of Microbiology & Biotechnology·Yota Tsuge, Hiroki Matsuzawa
Feb 27, 2021·Frontiers in Bioengineering and Biotechnology·Jie ChengJingwen Zhou
Apr 29, 2021·Applied Microbiology and Biotechnology·Jiaping WangLiming Liu
Dec 7, 2021·Frontiers in Bioengineering and Biotechnology·Deepanwita BanerjeeAindrila Mukhopadhyay

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Methods Mentioned

BETA
acetylation

Software Mentioned

EcoPaXX

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