Engineering DNA vaccines against infectious diseases

Acta Biomaterialia
Jihui LeeCorey J Bishop

Abstract

Engineering vaccine-based therapeutics for infectious diseases is highly challenging, as trial formulations are often found to be nonspecific, ineffective, thermally or hydrolytically unstable, and/or toxic. Vaccines have greatly improved the therapeutic landscape for treating infectious diseases and have significantly reduced the threat by therapeutic and preventative approaches. Furthermore, the advent of recombinant technologies has greatly facilitated growth within the vaccine realm by mitigating risks such as virulence reversion despite making the production processes more cumbersome. In addition, seroconversion can also be enhanced by recombinant technology through kinetic and nonkinetic approaches, which are discussed herein. Recombinant technologies have greatly improved both amino acid-based vaccines and DNA-based vaccines. A plateau of interest has been reached between 2001 and 2010 for the scientific community with regard to DNA vaccine endeavors. The decrease in interest may likely be attributed to difficulties in improving immunogenic properties associated with DNA vaccines, although there has been research demonstrating improvement and optimization to this end. Despite improvement, to the extent of our knowledge, ...Continue Reading

Citations

Oct 1, 2019·The Journal of Clinical Investigation·Nadine G RouphaelUNKNOWN HVTN 105 Protocol Team and the NIAID HIV Vaccine Trials Network
Jun 25, 2020·Pharmaceutics·Antonio José GuillotAna Melero
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Aug 14, 2020·Mutagenesis·Nevio Cimolai
May 21, 2019·Journal of Biomedical Materials Research. Part a·Jihui LeeCorey J Bishop
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Dec 11, 2021·Applied Microbiology and Biotechnology·Zrinka Matić, Maja Šantak

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Methods Mentioned

BETA
gene gun
transfection

Clinical Trials Mentioned

NCT01082692
NCT02431767
NCT01169077
NCT02431312
NCT02809443
NCT02887482
NCT02670187
NCT01405885
NCT02116205
NCT01877655

Software Mentioned

EndNote
DNAplotlib
SEAL

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