Engineering fluidic delays in paper-based devices using laser direct-writing

Lab on a Chip
P J W HeC L Sones

Abstract

We report the use of a new laser-based direct-write technique that allows programmable and timed fluid delivery in channels within a paper substrate which enables implementation of multi-step analytical assays. The technique is based on laser-induced photo-polymerisation, and through adjustment of the laser writing parameters such as the laser power and scan speed we can control the depth and/or the porosity of hydrophobic barriers which, when fabricated in the fluid path, produce controllable fluid delay. We have patterned these flow delaying barriers at pre-defined locations in the fluidic channels using either a continuous wave laser at 405 nm, or a pulsed laser operating at 266 nm. Using this delay patterning protocol we generated flow delays spanning from a few minutes to over half an hour. Since the channels and flow delay barriers can be written via a common laser-writing process, this is a distinct improvement over other methods that require specialist operating environments, or custom-designed equipment. This technique can therefore be used for rapid fabrication of paper-based microfluidic devices that can perform single or multistep analytical assays.

References

Jan 11, 2007·Angewandte Chemie·Andres W MartinezGeorge M Whitesides
Nov 22, 2008·Lab on a Chip·Andres W MartinezGeorge M Whitesides
Dec 10, 2008·Proceedings of the National Academy of Sciences of the United States of America·Andres W MartinezGeorge M Whitesides
Jun 25, 2009·Analytical Chemistry·Xu LiWei Shen
Jul 4, 2009·Analytical Chemistry·Emanuel CarrilhoGeorge M Whitesides
Dec 17, 2009·Analytical Chemistry·Andres W MartinezEmanuel Carrilho
Jan 26, 2010·Colloids and Surfaces. B, Biointerfaces·Xu LiWei Shen
Mar 20, 2010·Lab on a Chip·Elain FuPaul Yager
Mar 27, 2010·Analytical Chemistry·Emanuel CarrilhoGeorge M Whitesides
Apr 24, 2010·Analytical Chemistry·Hyeran Noh, Scott T Phillips
Jul 31, 2010·Lab on a Chip·Andres W MartinezGeorge M Whitesides
Aug 14, 2010·Sensors and Actuators. B, Chemical·Elain FuPaul Yager
Sep 3, 2010·Analytical Chemistry·Hyeran Noh, Scott T Phillips
Nov 26, 2010·Analytical Chemistry·Juuso OlkkonenTomi Erho
Jan 21, 2011·Analytical Chemistry·Jacqui L DelaneyWei Shen
Dec 6, 2011·Microfluidics and Nanofluidics·Elain FuPaul Yager
Mar 28, 2012·Lab on a Chip·Nicole K ThomScott T Phillips
Jun 11, 2014·Analytical Chemistry·Dimosthenis L GiokasAthanasios G Vlessidis
May 28, 2015·Biomicrofluidics·Peijun J W HeCollin L Sones

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Citations

Aug 6, 2019·Emerging Microbes & Infections·Maria Victoria HumbertMyron Christodoulides
Jul 2, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Siraprapa BoobphahomKwanwoo Shin
Aug 23, 2020·Micromachines·Brent KalishHideaki Tsutsui
Aug 7, 2019·Micromachines·Veasna SoumKwanwoo Shin
Oct 29, 2020·Scientific Reports·Arthur ZargaryanSam H Au
Dec 13, 2016·Analytical Chemistry·Yuanyuan YangCharles S Henry

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