Engineering highly effective antimicrobial selenium nanoparticles through control of particle size

Nanoscale
Tao HuangAndrea J O'Connor

Abstract

The overuse of antibiotics has induced the rapid development of antibiotic resistance in bacteria. As a result, antibiotic efficacy has become limited, and infection with multidrug-resistant bacteria is considered to be one of the largest global human health threats. Consequently, new, effective and safe antimicrobial agents need to be developed urgently. One promising candidate to address this requirement is selenium nanoparticles (Se NPs), which are made from the essential dietary trace element Se and have antimicrobial activity against Gram-positive bacteria. The size of nanomaterials can strongly affect their biophysical properties and functions; however, the effects of the size of Se NPs on their antibacterial efficacy has not been systematically investigated. Therefore, in this work, spherical Se NPs ranging from 43 to 205 nm in diameter were fabricated, and their mammalian cytotoxicity and antibacterial activity as a function of their size were systematically studied. The antibacterial activity of the Se NPs was shown to be strongly size dependent, with 81 nm Se NPs showing the maximal growth inhibition and killing effect of methicillin-sensitive and methicillin-resistant Staphylococcus aureus (MSSA and MRSA). The Se NPs...Continue Reading

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Citations

Sep 2, 2020·Journal of the Science of Food and Agriculture·José A Hernández-DíazSoledad García-Morales
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Dec 1, 2020·ACS Applied Materials & Interfaces·Tao HuangAndrea J O'Connor
Nov 22, 2021·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Eman M El El-SherbenySamr Kassem

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Methods Mentioned

BETA
transmission electron microscopy
Infrared Spectroscopy

Software Mentioned

SPSS

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