Engineering microbial pathways for production of bio-based chemicals from lignocellulosic sugars: current status and perspectives

Biotechnology for Biofuels
Jean Marie FrancoisNicolas Morin

Abstract

Lignocellulose is the most abundant biomass on earth with an annual production of about 2 × 1011 tons. It is an inedible renewable carbonaceous resource that is very rich in pentose and hexose sugars. The ability of microorganisms to use lignocellulosic sugars can be exploited for the production of biofuels and chemicals, and their concurrent biotechnological processes could advantageously replace petrochemicals' processes in a medium to long term, sustaining the emerging of a new economy based on bio-based products from renewable carbon sources. One of the major issues to reach this objective is to rewire the microbial metabolism to optimally configure conversion of these lignocellulosic-derived sugars into bio-based products in a sustainable and competitive manner. Systems' metabolic engineering encompassing synthetic biology and evolutionary engineering appears to be the most promising scientific and technological approaches to meet this challenge. In this review, we examine the most recent advances and strategies to redesign natural and to implement non-natural pathways in microbial metabolic framework for the assimilation and conversion of pentose and hexose sugars derived from lignocellulosic material into industrial rele...Continue Reading

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Citations

Jan 7, 2021·Bioresource Technology·Deokyeol JeongSoo Rin Kim
Feb 12, 2021·Biotechnology for Biofuels·Friederike GutmannKiran R Patil
Apr 25, 2021·Biotechnology for Biofuels·Peng NingJianming Yang
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Jul 21, 2021·Journal of Agricultural and Food Chemistry·Chung-Jen ChiangYun-Peng Chao
Aug 3, 2021·Current Opinion in Biotechnology·İpek ErgalSimon K-Mr Rittmann

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Methods Mentioned

BETA
deamination
genetic modifications

Software Mentioned

Dahms
NP

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