Engineering Microneedles for Therapy and Diagnosis: A Survey

Micromachines
Liping XieWei Qian

Abstract

Microneedle (MN) technology is a rising star in the point-of-care (POC) field, which has gained increasing attention from scientists and clinics. MN-based POC devices show great potential for detecting various analytes of clinical interests and transdermal drug delivery in a minimally invasive manner owing to MNs' micro-size sharp tips and ease of use. This review aims to go through the recent achievements in MN-based devices by investigating the selection of materials, fabrication techniques, classification, and application, respectively. We further highlight critical aspects of MN platforms for transdermal biofluids extraction, diagnosis, and drug delivery assisted disease therapy. Moreover, multifunctional MNs for stimulus-responsive drug delivery systems were discussed, which show incredible potential for accurate and efficient disease treatment in dynamic environments for a long period of time. In addition, we also discuss the remaining challenges and emerging trend of MN-based POC devices from the bench to the bedside.

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Citations

Apr 15, 2020·Micromachines·Jane Ru Choi, Kar Wey Yong
Dec 11, 2020·Assay and Drug Development Technologies·Jitendra Gupta Vanshita
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Mar 2, 2021·Advanced Healthcare Materials·Hazhir TeymourianJoseph Wang
May 1, 2021·Pharmaceutics·Tsu-Man ChiuNobutaka Hanagata
May 24, 2021·Drug Delivery and Translational Research·Afsoun KhosraviboroujeniAzade Taheri
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Aug 28, 2021·Advanced Healthcare Materials·Li ZhaoRyan F Donnelly

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Methods Mentioned

BETA
biosensing
surface plasmon resonances
blood
chip
RNA-seq
biosensors

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