Engineering Microphysiological Immune System Responses on Chips.

Trends in Biotechnology
Chris P MillerDeok-Ho Kim

Abstract

Tissues- and organs-on-chips are microphysiological systems (MPSs) that model the architectural and functional complexity of human tissues and organs that is lacking in conventional cell monolayer cultures. While substantial progress has been made in a variety of tissues and organs, chips recapitulating immune responses have not advanced as rapidly. This review discusses recent progress in MPSs for the investigation of immune responses. To illustrate recent developments, we focus on two cases in point: immunocompetent tumor microenvironment-on-a-chip devices that incorporate stromal and immune cell components and pathomimetic modeling of human mucosal immunity and inflammatory crosstalk. More broadly, we discuss the development of systems immunology-on-a-chip devices that integrate microfluidic engineering approaches with high-throughput omics measurements and emerging immunological applications of MPSs.

Citations

Oct 6, 2020·Frontiers in Immunology·Ingrid AnemanLana McClements
Dec 1, 2020·Frontiers in Oncology·Luigi Ombrato, Marco Montagner
Dec 21, 2020·Trends in Pharmacological Sciences·Chao MaWeiqiang Chen
Feb 16, 2021·ACS Biomaterials Science & Engineering·Seunggyu KimJessie S Jeon
Dec 19, 2020·Nature Reviews. Gastroenterology & Hepatology·Albert GoughD Lansing Taylor
Feb 4, 2021·APL Bioengineering·Jose M AyusoDavid J Beebe
Apr 3, 2021·Advanced Drug Delivery Reviews·Tengku Ibrahim MaulanaPeter Loskill
Apr 15, 2021·Advanced Biology·Andrea De PieriKarin Wuertz-Kozak
Apr 20, 2021·Advanced Healthcare Materials·Chao Tao, Dong-An Wang
May 1, 2021·Cancers·Elodie PramilAlexandre E Escargueil
Jun 5, 2021·Lab on a Chip·K PatersonM Zagnoni
Oct 7, 2021·American Journal of Physiology. Lung Cellular and Molecular Physiology·Dave Anuj LagowalaDeok-Ho Kim

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