Engineering multi-specific antibodies against HIV-1

Retrovirology
Neal N PadteDavid D Ho

Abstract

As increasing numbers of broadly neutralizing monoclonal antibodies (mAbs) against HIV-1 enter clinical trials, it is becoming evident that combinations of mAbs are necessary to block infection by the diverse array of globally circulating HIV-1 strains and to limit the emergence of resistant viruses. Multi-specific antibodies, in which two or more HIV-1 entry-targeting moieties are engineered into a single molecule, have expanded rapidly in recent years and offer an attractive solution that can improve neutralization breadth and erect a higher barrier against viral resistance. In some unique cases, multi-specific HIV-1 antibodies have demonstrated vastly improved antiviral potency due to increased avidity or enhanced spatiotemporal functional activity. This review will describe the recent advancements in the HIV-1 field in engineering monoclonal, bispecific and trispecific antibodies with enhanced breadth and potency against HIV-1. A case study will also be presented as an example of the developmental challenges these multi-specific antibodies may face on their path to the clinic. The tremendous potential of multi-specific antibodies against the HIV-1 epidemic is readily evident. Creativity in their discovery and engineering, a...Continue Reading

References

Apr 18, 1985·Nature·U D StaerzM J Bevan
Jan 1, 1994·AIDS Research and Human Retroviruses·A M EatonJ A Levy
Jul 14, 1998·Nature Biotechnology·A M MerchantP Carter
Aug 1, 2008·Nature·Jun LiuSriram Subramaniam
Sep 6, 2008·The Journal of Infectious Diseases·Jeffrey M JacobsonWilliam C Olson
Apr 18, 2009·Proceedings of the National Academy of Sciences of the United States of America·Joshua S KleinPamela J Bjorkman
Jun 16, 2009·Molecular Cell·Matthias J FeigeJohannes Buchner
Jul 3, 2009·Proceedings of the National Academy of Sciences of the United States of America·Naresh ChennamsettyBernhardt L Trout
Jun 22, 2011·Proceedings of the National Academy of Sciences of the United States of America·Wolfgang SchaeferChristian Klein
Aug 19, 2011·Nature·Laura M WalkerPascal Poignard
Nov 2, 2012·Proceedings of the National Academy of Sciences of the United States of America·Hugo MouquetPamela J Bjorkman
Jul 24, 2013·Proceedings of the National Academy of Sciences of the United States of America·Craig S PaceDavid D Ho
Mar 5, 2014·Nature·Nicole A Doria-RoseJohn R Mascola
May 24, 2014·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Ming SunDavid D Ho
Nov 26, 2014·Proceedings of the National Academy of Sciences of the United States of America·Devin SokDennis R Burton
Jan 31, 2015·Cell·Rachel P GalimidiPamela J Bjorkman
Feb 25, 2015·Nature·Matthew R GardnerMichael Farzan
Sep 4, 2015·Clinical and Experimental Immunology·Julie E LedgerwoodUNKNOWN VRC 602 Study Team
Dec 25, 2015·Science Translational Medicine·Rebecca M LynchUNKNOWN VRC 601 Study Team
Feb 11, 2016·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Marina BacacPablo Umana
Mar 1, 2016·Cell Host & Microbe·Barton F HaynesAndrew J McMichael

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Citations

Dec 21, 2018·Expert Review of Clinical Pharmacology·Andrea GiacomelliStefano Rusconi
Aug 4, 2019·Journal of Virology·David WenselMark Krystal
Jan 28, 2020·Annual Review of Medicine·Shelly T Karuna, Lawrence Corey
Nov 26, 2019·Current Opinion in HIV and AIDS·Marina Caskey
Aug 1, 2020·Current Opinion in HIV and AIDS·Marina Tuyishime, Guido Ferrari
May 21, 2019·Current Opinion in HIV and AIDS·Irene A AbelaAlexandra Trkola
Jul 17, 2020·Current HIV/AIDS Reports·Andrew Kapoor, C Sabrina Tan
Jan 11, 2020·Frontiers in Immunology·Bin SuChristiane Moog
Jul 16, 2020·Proceedings of the National Academy of Sciences of the United States of America·Pengfei WangDavid D Ho
Aug 3, 2019·Vaccines·Robin A Weiss, C Theo Verrips
Mar 11, 2020·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·Wanwisa PromsoteAmarendra Pegu
Oct 24, 2020·Gene Therapy·Kristie BloomPatrick Arbuthnot
Jun 15, 2021·Frontiers in Public Health·David A SpencerAnn J Hessell
Aug 7, 2021·Frontiers in Immunology·Stephen R Walsh, Michael S Seaman

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Methods Mentioned

BETA
glycosylation
X-ray
in
electrophoresis
transfection
ELISA

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