Engineering nanoscale surface features to sustain microparticle rolling in flow

ACS Nano
Surachate Kalasin, Maria M Santore

Abstract

Nanoscopic features of channel walls are often engineered to facilitate microfluidic transport, for instance when surface charge enables electro-osmosis or when grooves drive mixing. The dynamic or rolling adhesion of flowing microparticles on a channel wall holds potential to accomplish particle sorting or to selectively transfer reactive species or signals between the wall and flowing particles. Inspired by cell rolling under the direction of adhesion molecules called selectins, we present an engineered platform in which the rolling of flowing microparticles is sustained through the incorporation of entirely synthetic, discrete, nanoscale, attractive features into the nonadhesive (electrostatically repulsive) surface of a flow channel. Focusing on one example or type of nanoscale feature and probing the impact of broad systematic variations in surface feature loading and processing parameters, this study demonstrates how relatively flat, weakly adhesive nanoscale features, positioned with average spacings on the order of tens of nanometers, can produce sustained microparticle rolling. We further demonstrate how the rolling velocity and travel distance depend on flow and surface design. We identify classes of related surfaces ...Continue Reading

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Citations

Jul 29, 2015·Langmuir : the ACS Journal of Surfaces and Colloids·Victor V YashinAnna C Balazs
May 10, 2016·Langmuir : the ACS Journal of Surfaces and Colloids·Sumedha SharmaJacinta C Conrad
Oct 14, 2016·Langmuir : the ACS Journal of Surfaces and Colloids·John K Riley, Robert D Tilton
Nov 6, 2015·Frontiers in Microbiology·Angela SchwabFatah Kashanchi
Jun 15, 2021·Langmuir : the ACS Journal of Surfaces and Colloids·Zhou XuMaria M Santore

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