Engineering novel diagnostic modalities and implantable cytomimetic nanomaterials for next-generation medicine

Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation
Dean HoCarlo D Montemagno

Abstract

The advent of 21st century medicine will be based on a comprehensive approach to achieving the highly sensitive and specific detection of diseases, as well as the development of novel materials and devices based on biotic-abiotic interfacing as interventional modalities. Novel technologies that enable early identification of physiological changes will serve as a gateway tool for the proper treatment of these disorders. Toward the realization of these technologies, microfabrication and nanofabrication methods have been applied to biomedical systems that allow scientists to interact with cellular and molecular systems on their native size scales. Future enabling systems will build on the foundation composed of such devices. With respect to the envisioned fruition of biofunctional nanomaterials and systems, foundational studies of biological systems and molecules, as well as their interfacing with biocompatible materials, have produced a domain of components that can be integrated and engineered toward eventual cytomimetic materials for transplantation. In addition, the potential underscoring of their future applications in nanoscale medicine is based on the ability to engineer and design intelligent membrane/protein self-assembli...Continue Reading

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Citations

Jun 1, 2013·Reports on Progress in Physics·Rajagopalan ThiruvengadathanShubhra Gangopadhyay

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