Engineering of brain-like tissue constructs via 3D Cell-printing technology.

Biofabrication
Yu SongWei Sun

Abstract

The development of 3D Cell-printing technology contributes to the application of tissue constructs in vitro in neuroscience. Collecting neural cells from patients is an efficient way of monitoring health of an individual target, which, in turn, benefits the enhancement of medicines. The fabricated sample of neural cells is exposed to potential drugs for the analysis of neuron responses. 3D cell-printing as an emerging biofabrication technology has been widely used to mimic natural 3D models in in vitro tissue research, especially in vitro brain-like tissue constructs in neuroscience. Fabricated brain-like tissue constructs provide a 3D microenvironment for primary neural cells to grow within. After more than several weeks of in vitro culturing, the formation of neural circuits in structures equips them with the capability of sensitively responding to a stimulus. In this study, an in vitro layered brain-like tissue construct is first proposed and later developed by 3D cell-printing technology. The layered structure is systematically analyzed, starting from printing parameter optimization to biological functionality performance. The optimized diameter of printing nozzle and printing speed are 0.51 mm and 5 μl s-1, respectively, a...Continue Reading

References

Apr 8, 2003·Trends in Biotechnology·Vladimir MironovRoger R Markwald
Sep 28, 2007·The European Journal of Neuroscience·Eva HedlundOle Isacson
Jun 29, 2011·Advanced Functional Materials·Jennifer N Hanson ShepherdRalph G Nuzzo
Sep 3, 2013·Nature·Madeline A LancasterJuergen A Knoblich
Aug 6, 2014·Nature Biotechnology·Sean V Murphy, Anthony Atala
Dec 3, 2014·Progress in Neurobiology·Amy M HopkinsDavid L Kaplan
Dec 23, 2015·Biofabrication·Atabak Ghanizadeh TabrizWenmiao Shu
Feb 16, 2016·Nature Biotechnology·Hyun-Wook KangAnthony Atala
Jun 1, 2017·Nature Biotechnology·Madeline A LancasterJuergen A Knoblich
Nov 10, 2017·Biomaterials·Pei ZhuangSing Yian Chew
Dec 6, 2017·Frontiers in Bioengineering and Biotechnology·Michaela Thomas, Stephanie M Willerth
Feb 10, 2018·Trends in Biotechnology·Geoffrey PotjewydNigel M Hooper
May 8, 2018·Nature Biotechnology·Madeline A Lancaster
Jun 18, 2018·Journal of Cell Communication and Signaling·Derek M van PelWun Chey Sin
Jun 7, 2019·Nature Reviews. Neuroscience·Julia Cox, Ilana B Witten

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