Engineering of Corneal Tissue through an Aligned PVA/Collagen Composite Nanofibrous Electrospun Scaffold

Nanomaterials
Zhengjie WuShengli Mi

Abstract

Corneal diseases are the main reason of vision loss globally. Constructing a corneal equivalent which has a similar strength and transparency with the native cornea, seems to be a feasible way to solve the shortage of donated cornea. Electrospun collagen scaffolds are often fabricated and used as a tissue-engineered cornea, but the main drawback of poor mechanical properties make it unable to meet the requirement for surgery suture, which limits its clinical applications to a large extent. Aligned polyvinyl acetate (PVA)/collagen (PVA-COL) scaffolds were electrospun by mixing collagen and PVA to reinforce the mechanical strength of the collagen electrospun scaffold. Human keratocytes (HKs) and human corneal epithelial cells (HCECs) inoculated on aligned and random PVA-COL electrospun scaffolds adhered and proliferated well, and the aligned nanofibers induced orderly HK growth, indicating that the designed PVA-COL composite nanofibrous electrospun scaffold is suitable for application in tissue-engineered cornea.

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Citations

Nov 30, 2018·Current Drug Targets·Irene Anton-SalesDana Kralisch
Aug 29, 2020·Journal of Materials Science. Materials in Medicine·Rossana BoniAndrew N Clarkson
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Aug 10, 2021·Advanced Healthcare Materials·Nello FormisanoStefan Giselbrecht

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Methods Mentioned

BETA
confocal microscopy

Software Mentioned

Image Pro Plus ( IPP )

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