Engineering pattern formation and morphogenesis.

Biochemical Society Transactions
Jamie Davies, Fokion Glykofrydis

Abstract

The development of natural tissues, organs and bodies depends on mechanisms of patterning and of morphogenesis, typically (but not invariably) in that order, and often several times at different final scales. Using synthetic biology to engineer patterning and morphogenesis will both enhance our basic understanding of how development works, and provide important technologies for advanced tissue engineering. Focusing on mammalian systems built to date, this review describes patterning systems, both contact-mediated and reaction-diffusion, and morphogenetic effectors. It also describes early attempts to connect the two to create self-organizing physical form. The review goes on to consider how these self-organized systems might be modified to increase the complexity and scale of the order they produce, and outlines some possible directions for future research and development.

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Citations

May 22, 2021·ACS Synthetic Biology·Fokion GlykofrydisJamie A Davies
May 28, 2021·IScience·Mo R Ebrahimkhani, Michael Levin
Nov 30, 2021·Microbial Biotechnology·Martina Oliver HuidobroMark Isalan

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Methods Mentioned

BETA
urine collecting

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