Engineering principles of clinical cell-based tissue engineering

The Journal of Bone and Joint Surgery. American Volume
George F MuschlerLinda G Griffith

Abstract

Tissue engineering is a rapidly evolving discipline that seeks to repair, replace, or regenerate specific tissues or organs by translating fundamental knowledge in physics, chemistry, and biology into practical and effective materials, devices, systems, and clinical strategies. Stem cells and progenitors that are capable of forming new tissue with one or more connective tissue phenotypes are available from many adult tissues and are defined as connective tissue progenitors. There are four major cell-based tissue-engineering strategies: (1) targeting local connective tissue progenitors where new tissue is desired, (2) transplanting autogenous connective tissue progenitors, (3) transplanting culture-expanded or modified connective tissue progenitors, and (4) transplanting fully formed tissue generated in vitro or in vivo. Stem cell function is controlled by changes in stem cell activation and self-renewal or by changes in the proliferation, migration, differentiation, or survival of the progeny of stem cell activation, the downstream progenitor cells. Three-dimensional porous scaffolds promote new tissue formation by providing a surface and void volume that promotes the attachment, migration, proliferation, and desired differenti...Continue Reading

References

Jun 21, 1977·Journal of Theoretical Biology·J Wei, M B Russ
Sep 1, 1991·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·A I Caplan
Jan 1, 1989·Journal of Orthopaedic Trauma·J F ConnollyR Dehne
Jun 1, 1983·Developmental Biology·D M Jargiello, A I Caplan
Jul 1, 1980·Journal of Biomedical Materials Research·N DagalakisI V Yannas
Dec 1, 1993·Acta Orthopaedica Scandinavica·N K GargS Sharma
May 14, 1993·Science·R Langer, J P Vacanti
Jul 1, 1996·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·R K Aaron, D M Ciombor
Sep 15, 1996·Archives of Biochemistry and Biophysics·A M GarciaA J Grodzinsky
Oct 31, 1997·The Journal of Bone and Joint Surgery. American Volume·C B Frank, D W Jackson
Jul 1, 1997·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·A K MajorsG F Muschler
Mar 7, 1998·Cell Transplantation·K SuzukiG C Weir
Aug 15, 1998·Biochemical and Biophysical Research Communications·C HuardJ P Tremblay
Oct 3, 1998·JAMA : the Journal of the American Medical Association·J S FinkelsteinR M Neer
Dec 17, 1998·Journal of Biomedical Materials Research·J O HollingerJ Wozney
Jan 7, 1999·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·A M GarciaA J Grodzinsky
Apr 2, 1999·Science·M F PittengerD R Marshak
Apr 21, 1999·Current Opinion in Biotechnology·J A Hubbell
Apr 30, 1999·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·L A SolchagaA I Caplan
Jun 15, 1999·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·M IsobeT Amagasa
Jul 9, 1999·Journal of Biomedical Materials Research·T GrothD Paul
Jul 15, 1999·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·G D'IppolitoG A Howard
Jul 23, 1999·Annals of the New York Academy of Sciences·S Abdel-AleemJ E Lowe
Jul 23, 1999·Annals of the New York Academy of Sciences·H WuC K Colton
Feb 7, 2001·American Journal of Physiology. Cell Physiology·L A Kunz-SchughartK Groebe

❮ Previous
Next ❯

Citations

Jul 14, 2005·Current Opinion in Otolaryngology & Head and Neck Surgery·Oneida Arosarena
Oct 22, 2005·Orthodontics & Craniofacial Research·A Balic, M Mina
Jul 11, 2006·Scandinavian Journal of Surgery : SJS : Official Organ for the Finnish Surgical Society and the Scandinavian Surgical Society·C HungG F Muschler
Mar 3, 2007·The Journal of Bone and Joint Surgery. American Volume·William G De LongTracy Watson
Oct 4, 2007·Skeletal Radiology·T W Bauer
Aug 31, 2007·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Ken KumagaiGeorge F Muschler
Jun 12, 2008·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Debi P MukherjeeByron K Hayes
Apr 19, 2008·Journal of Biomaterials Science. Polymer Edition·L MoroniC A van Blitterswijk
Aug 6, 2008·Journal of Biomedical Materials Research. Part a·Eun Jung KimShuvo Roy
Oct 25, 2008·Current Urology Reports·Mark E Furth, Anthony Atala
Apr 2, 2009·Journal of Periodontology·Bradley S McAllisterAron Gonshor
Mar 19, 2009·Tissue Engineering. Part a·Craig K Griffith, Steven C George
Nov 28, 2009·The International Journal of Artificial Organs·Ingrid GarzonAntonio Campos
Feb 6, 2010·Proceedings of the National Academy of Sciences of the United States of America·Olga TsigkouCraig Neville
Feb 4, 2010·Equine Veterinary Journal·D D Frisbie, R K W Smith
Oct 30, 2009·Tissue Engineering. Part a·Saey Tuan Barnabas HoJames Hoi Hui
Dec 29, 2009·Journal of Materials Science. Materials in Medicine·Hanifeh KhayyeriPatrick J Prendergast
Feb 27, 2010·Journal of Biomedical Materials Research. Part a·H NitzscheK Mäder
Oct 14, 2010·Advanced Materials·Jae Sung LeeWilliam L Murphy
Mar 2, 2011·Journal of Tissue Engineering and Regenerative Medicine·Femke VerseijdenGerjo J V M van Osch
Feb 4, 2011·Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine·P Jayakumar, L Di Silvio
Mar 16, 2012·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Ken KumagaiTomoyuki Saito
Jun 16, 2012·Annals of Biomedical Engineering·Tonya CarallaGeorge Muschler
Aug 7, 2012·Tissue Engineering. Part a·Junchao XingJianzhong Xu
Feb 9, 2012·Journal of Cancer Research and Clinical Oncology·Daniel-Johannes TilkornSammy Al-Benna
Apr 26, 2012·Journal of Biomaterials Applications·Elaine R DurhamStephen J Russell
Apr 24, 2012·Tissue Engineering. Part a·Cathal J KearneyMyron Spector
Jul 25, 2012·Journal of Materials Science. Materials in Medicine·Forough HafeziMohammad Reza Nourani
Nov 28, 2012·Advanced Healthcare Materials·Maria Ann WoodruffDietmar Werner Hutmacher
Dec 12, 2012·Tissue Engineering. Part a·Viviane LuangphakdyGeorge F Muschler
Aug 31, 2013·Nature Protocols·John P MorganAbraham D Stroock
Jun 15, 2013·Journal of Biomedical Materials Research. Part a·Venkata P MantripragadaAmbalangodage C Jayasuriya
Oct 2, 2013·European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes·Marina Gabriela Monteiro Carvalho Mori da CunhaJaan Toelen
Oct 25, 2013·Tissue Engineering. Part C, Methods·Jordan A WhislerRoger D Kamm
Aug 1, 2014·Journal of Orthopaedic Surgery and Research·Yun ZhangTomoyuki Saito
Jun 11, 2014·Experimental Biology and Medicine·Cindy S ChengGeorge A Truskey

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adult Stem Cells

Adult stem cells reside in unique niches that provide vital cues for their survival, self-renewal, and differentiation. They hold great promise for use in tissue repair and regeneration as a novel therapeutic strategies. Here is the latest research.

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.