Engineering reaction-diffusion networks with properties of neural tissue

Lab on a Chip
Thomas LitschelSeth Fraden

Abstract

We present an experimental system of networks of coupled non-linear chemical reactors, which we theoretically model within a reaction-diffusion framework. The networks consist of patterned arrays of diffusively coupled nanoliter-scale reactors containing the Belousov-Zhabotinsky (BZ) reaction. Microfluidic fabrication techniques are developed that provide the ability to vary the network topology and the reactor coupling strength and offer the freedom to choose whether an arbitrary reactor is inhibitory or excitatory coupled to its neighbor. This versatile experimental and theoretical framework can be used to create a wide variety of chemical networks. Here we design, construct and characterize chemical networks that achieve the complexity of central pattern generators (CPGs), which are found in the autonomic nervous system of a variety of organisms.

References

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Apr 29, 2014·Physical Chemistry Chemical Physics : PCCP·Ning LiSeth Fraden
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Citations

Apr 23, 2019·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Andrew Adamatzky
Sep 24, 2020·Chemical Communications : Chem Comm·Marcello A BudroniAli Abou-Hassan
Jul 28, 2019·Nature Communications·Liangfei TianStephen Mann
Jan 4, 2020·The Journal of Physical Chemistry. a·Ilya L Mallphanov, Vladimir K Vanag
Apr 23, 2021·Physical Chemistry Chemical Physics : PCCP·Ilya L Mallphanov, Vladimir K Vanag
May 29, 2021·The Journal of Physical Chemistry. B·Maria Eleni MoustakaSeth Fraden
Aug 10, 2021·Physical Chemistry Chemical Physics : PCCP·Marcello A BudroniFederico Rossi
Dec 15, 2020·The Journal of Physical Chemistry. B·James SheehySeth Fraden
Feb 23, 2020·The Journal of Physical Chemistry Letters·Marcello A BudroniFederico Rossi

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Methods Mentioned

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