Engineering Stem Cells for Biomedical Applications

Advanced Healthcare Materials
Perry T YinKi-Bum Lee

Abstract

Stem cells are characterized by a number of useful properties, including their ability to migrate, differentiate, and secrete a variety of therapeutic molecules such as immunomodulatory factors. As such, numerous pre-clinical and clinical studies have utilized stem cell-based therapies and demonstrated their tremendous potential for the treatment of various human diseases and disorders. Recently, efforts have focused on engineering stem cells in order to further enhance their innate abilities as well as to confer them with new functionalities, which can then be used in various biomedical applications. These engineered stem cells can take on a number of forms. For instance, engineered stem cells encompass the genetic modification of stem cells as well as the use of stem cells for gene delivery, nanoparticle loading and delivery, and even small molecule drug delivery. The present Review gives an in-depth account of the current status of engineered stem cells, including potential cell sources, the most common methods used to engineer stem cells, and the utilization of engineered stem cells in various biomedical applications, with a particular focus on tissue regeneration, the treatment of immunodeficiency diseases, and cancer.

References

Nov 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·J A WolffT Friedmann
May 1, 1987·Cell and Tissue Kinetics·A J FriedensteinU V Gerasimov
May 1, 1986·Stroke; a Journal of Cerebral Circulation·J B BedersonH Bartkowski
Jun 1, 1965·The Journal of Comparative Neurology·J Altman, G D Das
Oct 6, 1994·The New England Journal of Medicine·M BrittbergL Peterson
Dec 10, 1996·Proceedings of the National Academy of Sciences of the United States of America·B HessV Gieselmann
Jun 1, 1997·Transplantation Proceedings·Z Q JiaR K Li
Jan 7, 1998·Journal of Neuroscience Research·S L ShumanM S Beattie
Mar 21, 1998·Human Gene Therapy·M K ChuahT VandenDriessche
May 9, 1998·Proceedings of the National Academy of Sciences of the United States of America·O Saucedo-CardenasO M Conneely
Sep 19, 1998·Journal of Controlled Release : Official Journal of the Controlled Release Society·Y H ChoiS W Kim
Oct 17, 1998·Science·C SuriG D Yancopoulos
Nov 6, 1998·Pharmacology & Therapeutics·P D Robbins, S C Ghivizzani
Nov 6, 1998·Science·J A ThomsonJ M Jones
Apr 13, 1999·Journal of Molecular and Cellular Cardiology·R K LiD A Mickle
Jun 15, 1999·Toxicologic Pathology·B D CarT D Anderson
Jul 9, 1999·Journal of Biomedical Materials Research·W T GodbeyA G Mikos
Jul 23, 1999·Brain Pathology·C N SvendsenT Ostenfeld
Jan 21, 2000·Journal of Controlled Release : Official Journal of the Controlled Release Society·M H SheridanD J Mooney
Feb 26, 2000·Science·F H Gage
Mar 31, 2000·Experimental Cell Research·H Walczak, P H Krammer
Mar 31, 2000·Nature Medicine·G ThurstonG D Yancopoulos
Sep 6, 2000·Nature Biotechnology·H PetiteG Guillemin
Oct 31, 2000·The Journal of Biological Chemistry·A YamaguchiM Tohyama
Mar 29, 2001·Physiological Reviews·N Baumann, D Pham-Dinh
Oct 5, 2001·Clinical Neuropharmacology·R J DumontA S Dumont
Oct 13, 2001·Science·R K Bruick, S L McKnight
Oct 18, 2001·Clinical Orthopaedics and Related Research·A R PooleS Laverty

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Citations

May 3, 2018·Advanced Healthcare Materials·Shupei QiaoWeiming Tian
Dec 2, 2017·Advanced Healthcare Materials·Timothée Baudequin, Maryam Tabrizian
Jul 25, 2019·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Heather BranscomeFatah Kashanchi
Jun 20, 2017·Oxidative Medicine and Cellular Longevity·Magdalena SkoniecznaRafal J Buldak
Dec 20, 2019·Angiologii︠a︡ i sosudistai︠a︡ khirurgii︠a︡ = Angiology and vascular surgery·Milica MaslovaricEmilija Delević
Jun 24, 2015·Stem Cells International·Xianyun WangBaoyong Yan

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