Engineering the gut microbiota to treat chronic diseases.

Applied Microbiology and Biotechnology
Noura S DosokySean S Davies

Abstract

Gut microbes play vital roles in host health and disease. A number of commensal bacteria have been used as vectors for genetic engineering to create living therapeutics. This review highlights recent advances in engineering gut bacteria for the treatment of chronic diseases such as metabolic diseases, cancer, inflammatory bowel diseases, and autoimmune disorders. KEY POINTS: • Bacterial homing to tumors has been exploited to deliver therapeutics in mice models. • Engineered bacteria show promise in mouse models of metabolic diseases. • Few engineered bacterial treatments have advanced to clinical studies.

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Citations

Feb 9, 2021·Frontiers in Medicine·Elisavet StavropoulouEugenia Bezirtzoglou
Nov 25, 2020·International Journal of Molecular Sciences·Minjeong KangSuhyung Cho
Jun 18, 2021·Advanced Drug Delivery Reviews·Xi HuDaishun Ling
Aug 3, 2021·Journal of Immunology Research·Shunyu YaoXiaolu Liu

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Clinical Trials Mentioned

NCT03516487

Software Mentioned

Humira

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