Engineering the heterotrophic carbon sources utilization range of Ralstonia eutropha H16 for applications in biotechnology

Critical Reviews in Biotechnology
Elena VolodinaAlexander Steinbüchel

Abstract

Ralstonia eutropha H16 is an interesting candidate for the biotechnological production of polyesters consisting of hydroxy- and mercaptoalkanoates, and other compounds. It provides all the necessary characteristics, which are required for a biotechnological production strain. Due to its metabolic versatility, it can convert a broad range of renewable heterotrophic resources into diverse valuable compounds. High cell density fermentations of the non-pathogenic R. eutropha can be easily performed. Furthermore, this bacterium is accessible to engineering of its metabolism by genetic approaches having available a large repertoire of genetic tools. Since the complete genome sequence of R. eutropha H16 has become available, a variety of transcriptome, proteome and metabolome studies provided valuable data elucidating its complex metabolism and allowing a systematic biology approach. However, high production costs for bacterial large-scale production of biomass and biotechnologically valuable products are still an economic challenge. The application of inexpensive raw materials could significantly reduce the expenses. Therefore, the conversion of diverse substrates to polyhydroxyalkanoates by R. eutropha was steadily improved by optim...Continue Reading

References

Jul 1, 1984·Journal of Bacteriology·P Schobert, B Bowien
Mar 14, 2001·Journal of Biotechnology·J Yu
May 3, 2003·FEMS Microbiology Letters·Tina Lütke-Eversloh, Alexander Steinbüchel
Dec 6, 2005·Journal of Health Care for the Poor and Underserved·Gail E WyattJohn K Williams
Apr 29, 2006·Journal of Molecular Microbiology and Biotechnology·Tanja BurgdorfBärbel Friedrich
Jun 9, 2006·Journal of Industrial Microbiology & Biotechnology·Thomas M KeenanStuart W Tanenbaum
Sep 12, 2006·Nature Biotechnology·Anne PohlmannBotho Bowien
Jan 8, 2008·Bioscience, Biotechnology, and Biochemistry·Richard HaasFlorian Tobias Zepf
Oct 30, 2008·Journal of Molecular Microbiology and Biotechnology·Rainer Cramm
Oct 30, 2008·Journal of Molecular Microbiology and Biotechnology·Frank Reinecke, Alexander Steinbüchel
Mar 10, 2009·International Journal of Biological Sciences·Sung-Eun LeeJian Yu
Feb 27, 2010·Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry·Oliver LenzBärbel Friedrich
Apr 10, 2010·Journal of Applied Physiology·R W KenefickM N Sawka
Jun 11, 2010·Applied Microbiology and Biotechnology·Yung-Hun YangAnthony J Sinskey
Jun 25, 2010·The Journal of Physical Chemistry. B·Rajeev S AssaryLarry A Curtiss
Jun 29, 2010·Nature Reviews. Microbiology·Bernd H A Rehm
Aug 17, 2010·Journal of Bacteriology·Christopher J BrighamAnthony J Sinskey
Aug 20, 2010·Journal of Bioscience and Bioengineering·Suchada Chanprateep
Dec 21, 2010·Applied and Environmental Microbiology·Shanna SichwartAlexander Steinbüchel
Feb 1, 2011·Applied and Environmental Microbiology·Matthias RabergAlexander Steinbüchel
Feb 1, 2011·Applied Microbiology and Biotechnology·Kumar SudeshYan-Fen Lee
Mar 15, 2011·Applied and Environmental Microbiology·Charles F BuddeAnthony J Sinskey

❮ Previous
Next ❯

Citations

Dec 14, 2017·Critical Reviews in Biotechnology·Matthias RabergAlexander Steinbüchel
Nov 17, 2019·International Journal of Molecular Sciences·Miriam González-VillanuevaKang Lan Tee
Jul 13, 2019·Biotechnology for Biofuels·Carina Windhorst, Johannes Gescher
Sep 11, 2017·Applied Microbiology and Biotechnology·Hisashi ArikawaTetsuya Fujiki
Jun 27, 2019·Biotechnology for Biofuels·Christian Arenas-LópezKlaus Winzer
May 26, 2018·World Journal of Microbiology & Biotechnology·Gurusamy Kutralam-Muniasamy, Fermín Peréz-Guevara
Jul 22, 2018·Applied and Environmental Microbiology·Swathi AlagesanNigel P Minton
Sep 9, 2020·The Science of the Total Environment·Mengying XuTian Zhang
Mar 18, 2021·Critical Reviews in Biotechnology·Kai-Hee HuongA A Amirul
Jul 6, 2021·Metabolic Engineering·Joshua Luke GascoyneNaglis Malys
Jun 28, 2018·ACS Synthetic Biology·Abayomi Oluwanbe JohnsonTuck Seng Wong
Sep 12, 2021·Journal of Bioscience and Bioengineering·Dyah Candra Hapsari SubagyoToshiaki Fukui

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bioinformatics in Biomedicine

Bioinformatics in biomedicine incorporates computer science, biology, chemistry, medicine, mathematics and statistics. Discover the latest research on bioinformatics in biomedicine here.