Engraftment of human kidney tissue in rat radiation chimera: I. A new model of human kidney allograft rejection

Transplantation
B DekelY Reisner

Abstract

We have recently shown that lethally irradiated normal strains of mice and rats, reconstituted with bone marrow from severe combined immune deficiency (SCID) mice, can be engrafted with human peripheral blood mononuclear cells (PBMC). The feasibility of transplanting human renal tissue under the kidney capsule of the SCID/Lewis and SCID/nude radiation chimera and the effects of intraperitoneal infusion of allogeneic human PBMC on the human renal implants were investigated by histology, electron microscopy, immunohistochemistry, and fluorescence-activated cell sorter analysis. Sequential evaluation of the human renal implants from 10 days to 2 months after transplantation showed that human parenchymal elements survive in the implants up to 2 months after transplantation. The overall architecture of the transplanted kidney tissue and the normal structure of individual cells in the glomeruli and tubuli were preserved. Infusion of allogeneic human PBMC after kidney implantation resulted in patchy cellular infiltrates, composed mainly of activated human T cells, and led to prompt rejection of the human renal tissue, whereas no signs of inflammation were observed in human renal implants of chimeric rats that did not receive human PBM...Continue Reading

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Citations

Jan 27, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·E IlanE Galun
Aug 2, 2007·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Marc R Hammerman
Mar 13, 2003·Kidney International·Marc R Hammerman
Dec 26, 2001·Current Opinion in Nephrology and Hypertension·Marc R Hammerman
Jun 14, 2006·PLoS Medicine·Smadar Eventov-FriedmanY Reisner
Dec 7, 2006·Proceedings of the National Academy of Sciences of the United States of America·Anna AronovichY Reisner
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May 26, 2004·Transplant Immunology·B Dekel, Y Reisner
Apr 23, 2004·Expert Opinion on Biological Therapy·B Dekel, Y Reisner
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Sep 10, 2002·American Journal of Physiology. Renal Physiology·Marc R Hammerman
May 17, 2001·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Sharon A Rogers, Marc R Hammerman
Jul 13, 2001·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Sharon A Rogers, Marc R Hammerman

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