Engraftment Syndrome after Autologous Stem Cell Transplantation: An Update Unifying the Definition and Management Approach

Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation
Robert Frank CornellWilliam R Drobyski

Abstract

Engraftment syndrome (ES) encompasses a continuum of periengraftment complications after autologous hematopoietic stem cell transplantation. ES may include noninfectious fever, skin rash, diarrhea, hepatic dysfunction, renal dysfunction, transient encephalopathy, and capillary leak features, such as noncardiogenic pulmonary infiltrates, hypoxia, and weight gain with no alternative etiologic basis other than engraftment. Given its pleiotropic clinical presentation, the transplant field has struggled to clearly define ES and related syndromes. Here, we present a comprehensive review of ES in all documented disease settings. Furthermore, we discuss the proposed risk factors, etiology, and clinical relevance of ES. Finally, our current approach to ES is included along with a proposed treatment algorithm for the management of this complication.

References

Nov 8, 1979·The New England Journal of Medicine·E L ReinherzS F Schlossman
Oct 6, 1997·Bone Marrow Transplantation·J L ByrneN H Russell
Jul 4, 2001·Bone Marrow Transplantation·T R Spitzer
Sep 25, 2001·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·S A KhanJ S Moreb
Jan 31, 2006·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Leona HolmbergGeorge B McDonald
Oct 10, 2006·Clinical Lymphoma & Myeloma·Jed Abraham KatzelDavid H Vesole
Sep 25, 2007·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Javier Bolaños-MeadeGeorgia B Vogelsang
Jan 29, 2008·European Journal of Haematology·Angela DispenzieriMorie A Gertz
Sep 3, 2008·Bone Marrow Transplantation·W R DrobyskiW Grossman
Nov 15, 2008·Cancer Immunology, Immunotherapy : CII·Christine GalustianAngus G Dalgleish
Jun 16, 2009·Human Pathology·Kay Washington, Madan Jagasia
Oct 19, 2010·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Christopher H CogbillRichard A Komorowski
Mar 29, 2011·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Hillard M LazarusDavid Kaplan
Apr 19, 2011·Bone Marrow Transplantation·R Lopes da SilvaA B de Sousa
Jun 29, 2013·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Robert Frank CornellWilliam R Drobyski
Jul 23, 2013·Journal of the American Academy of Dermatology·Anna H ChaconGeorge W Elgart
Jun 11, 2014·Blood·Gérard Socié, Jerome Ritz
Aug 5, 2014·Bone Marrow Transplantation·F OtegbeyeH M Lazarus
Jan 13, 2015·Bone Marrow Transplantation·T R Spitzer
Feb 3, 2015·Bone Marrow Transplantation·R P Gale, H M Lazarus
Apr 11, 2015·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Vaishali SanchorawalaDavid C Seldin

❮ Previous
Next ❯

Citations

Oct 11, 2016·Blood Research·Young-Ho Lee, Wee-Jin Rah
Oct 8, 2016·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Michael ScordoCraig S Sauter
Oct 16, 2018·Journal of Oncology Pharmacy Practice : Official Publication of the International Society of Oncology Pharmacy Practitioners·Sweta U PatelDoyun Park
May 10, 2019·Bone Marrow Transplantation·Alessia CampagnaAgostino Tafuri
Apr 13, 2020·Clinical Transplantation·Andrew GrantTracey A O'Brien
Feb 13, 2020·British Journal of Haematology·Michael Scordo, Sergio A Giralt
Jun 26, 2020·European Respiratory Review : an Official Journal of the European Respiratory Society·Samran HaiderAyman O Soubani
Jul 28, 2019·Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis·Talha BadarAnita D'Souza
Nov 5, 2019·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Steven D Billings
Jan 14, 2021·Journal of Oncology Pharmacy Practice : Official Publication of the International Society of Oncology Pharmacy Practitioners·Kaitlyn E KowalskiAshley I Richards
Mar 21, 2021·International Journal of Dermatology·Bharath BaluKlaus F Helm
Jun 9, 2021·La Revue de médecine interne·A BichonJ Carvelli
Jun 18, 2021·Clinical Journal of the American Society of Nephrology : CJASN·Matthew H AbramsonInsara Jaffer Sathick

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Biology: Molecular Imaging

Molecular imaging enables noninvasive imaging of key molecules that are crucial to tumor biology. Discover the latest research in molecular imaging in cancer biology in this feed.

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.

Allogenic & Autologous Therapies

Allogenic therapies are generated in large batches from unrelated donor tissues such as bone marrow. In contrast, autologous therapies are manufactures as a single lot from the patient being treated. Here is the latest research on allogenic and autologous therapies.