Engulfment and cell motility 1 (ELMO1) and apolipoprotein A1 (APOA1) as candidate genes for sickle cell nephropathy.

British Journal of Haematology
Santosh L SarafVictor R Gordeuk

Abstract

Sickle cell disease (SCD) and apolipoprotein L1 (APOL1) G1/G2 variants increase chronic kidney disease (CKD) risk in African Americans by poorly understood mechanisms. We applied bioinformatics to identify new candidate genes associated with SCD-related CKD. An interaction network demonstrated APOA1 connecting haemoglobin subunit β (HBB) and APOL1 with 36 other candidate genes. Gene expression revealed upregulation of engulfment and cell motility 1 (ELMO1) and downregulation of APOA1 in the kidney cortex of SCD versus non-SCD mice. Analysis of candidate genes identified ELMO1 rs10951509 to be associated with albuminuria and APOA1 rs11216132 with haemoglobinuria in patients with SCD. A bioinformatic approach highlights ELMO1 and APOA1 as potentially associated with SCD nephropathy.

References

Dec 19, 2003·American Journal of Human Genetics·Christopher S CarlsonDeborah A Nickerson
Sep 12, 2007·PLoS Pathogens·Justin WidenerStephen Hajduk
Jan 10, 2009·Nature Protocols·Da Wei HuangRichard A Lempicki
Jan 27, 2009·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Michael F FlessnerErrol Crook
May 6, 2009·Annals of Internal Medicine·Andrew S LeveyUNKNOWN CKD-EPI (Chronic Kidney Disease Epidemiology Collaboration)
Aug 7, 2010·Journal of the American Society of Nephrology : JASN·Barry I FreedmanMartin R Pollak
Jan 31, 2012·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Oemer-Necmi GoekBrad C Astor
Mar 13, 2014·Atherosclerosis·Julio A Lamprea-MontealegreBrad C Astor
Jul 1, 2014·Nature Reviews. Microbiology·Etienne PaysDavid Pérez-Morga
Jul 25, 2015·Haematologica·Santosh L SarafVictor R Gordeuk
Dec 17, 2015·Clinical Journal of the American Society of Nephrology : CJASN·Paul DrawzJane Little
Feb 10, 2016·Proceedings of the National Academy of Sciences of the United States of America·Catherine K HathawayMasao Kakoki

❮ Previous
Next ❯

Citations

Jun 17, 2021·British Journal of Haematology·Idris BoudhabhayVincent Audard

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anemia

Anemia develops when your blood lacks enough healthy red blood cells. Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. Here is the latest research on anemia.

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.