Engulfment signals and the phagocytic machinery for apoptotic cell clearance

Experimental & Molecular Medicine
Seung-Yoon Park, In-San Kim

Abstract

The clearance of apoptotic cells is an essential process for tissue homeostasis. To this end, cells undergoing apoptosis must display engulfment signals, such as 'find-me' and 'eat-me' signals. Engulfment signals are recognized by multiple types of phagocytic machinery in phagocytes, leading to prompt clearance of apoptotic cells. In addition, apoptotic cells and phagocytes release tolerogenic signals to reduce immune responses against apoptotic cell-derived self-antigens. Here we discuss recent advances in our knowledge of engulfment signals, the phagocytic machinery and the signal transduction pathways for apoptotic cell engulfment.

References

Jun 17, 2000·Science·P A OldenborgF P Lindberg
Aug 23, 2000·The Journal of Biological Chemistry·B ZhouP H Weigel
May 11, 2001·Nature·R S ScottG K Matsushima
Sep 6, 2001·Cell Death and Differentiation·R A Schlegel, P Williamson
May 10, 2002·Nature·Rikinari HanayamaShigekazu Nagata
Apr 12, 2003·Developmental Cell·Swathi ArurDavid K Han
Oct 31, 2003·Essays in Biochemistry·Aimee M deCathelineau, Peter M Henson
Dec 4, 2003·Apoptosis : an International Journal on Programmed Cell Death·S M van den EijndeC Vermeij-Keers
Dec 22, 2004·The Journal of Cell Biology·Andrew DevittChristopher D Gregory
Feb 16, 2005·Journal of Neuroimmunology·Fernando Leonardi-EssmannPeter J Gebicke-Haerter
Sep 23, 2006·Journal of Cellular and Molecular Medicine·Julia KzhyshkowskaS Goerdt
Nov 15, 2006·The Journal of Experimental Medicine·Michael E GreenbergStanley L Hazen
Nov 23, 2006·Current Biology : CB·Robert S KissKodi S Ravichandran
Dec 26, 2006·Nature Medicine·Michel ObeidGuido Kroemer
Jan 6, 2007·PloS One·Yannick HamonGiovanna Chimini
Oct 26, 2007·Nature·Masanori MiyanishiShigekazu Nagata
Oct 27, 2007·Cell Death and Differentiation·S-Y ParkI-S Kim
Dec 20, 2007·The Journal of Biological Chemistry·Christoph PeterKirsten Lauber
Jan 16, 2008·The Journal of Experimental Medicine·Mark A WalletRoland Tisch
Jan 31, 2008·The Journal of Biological Chemistry·Seung-Yoon ParkIn-San Kim
Feb 6, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Helena PaïdassiPhilippe Frachet

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Citations

Jan 10, 2018·Frontiers in Immunology·Niloofar Karaji, Quentin J Sattentau
Nov 30, 2018·European Journal of Immunology·Joana VitalléFrancisco Borrego
Nov 27, 2019·Journal of Clinical Medicine·Amir TajbakhshAmirhossein Sahebkar
Mar 7, 2020·International Reviews of Immunology·Vijay Kumar
Jun 20, 2020·Chemical Communications : Chem Comm·Riki ToitaJeong-Hun Kang
Jun 28, 2019·Archives of Pharmacal Research·Seong-Ah ShinChang Sup Lee
Jun 1, 2018·Annual Review of Vision Science·Sean M Silverman, Wai T Wong
Apr 17, 2020·Frontiers in Immunology·Ioannis KourtzelisTriantafyllos Chavakis
May 23, 2019·Journal for Immunotherapy of Cancer·Davide BedognettiUNKNOWN Society for Immunotherapy of Cancer (SITC) Cancer Immune Responsiveness Task Force and Working Groups
Aug 23, 2019·Biomolecules·Seung-Yoon Park, In-San Kim
Dec 5, 2019·Frontiers in Immunology·Andrea Kristina HorstLinda Diehl
Aug 23, 2020·International Journal of Molecular Sciences·Chiara PanicucciClaudio Bruno
Nov 21, 2018·Journal of Extracellular Vesicles·Begoña Pérez-CabezasAnabela Cordeiro da Silva
Jan 10, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Po-Hsiang ChenSzecheng J Lo
Nov 13, 2020·The FEBS Journal·Camila Castillo FerrerGabriel Ichim
Jul 23, 2020·Shock·Yutian LiGuo-Chang Fan
Jan 4, 2021·Journal of Controlled Release : Official Journal of the Controlled Release Society·Riki ToitaJeong-Hun Kang
Jan 14, 2021·Cellular and Molecular Life Sciences : CMLS·Camilla S A Davan-WettonTrinidad Montero-Melendez
Jul 20, 2020·Trends in Microbiology·Georgina C DowdKeith Ireton
Jan 19, 2021·Biochemical Pharmacology·Marianna LovásziGyörgy Haskó
Feb 24, 2021·Glia·Dave E MarzanJames L Salzer
Sep 18, 2018·Developmental Cell·Lena M KutscherShai Shaham
May 5, 2018·Metabolism: Clinical and Experimental·Anouar Hafiane, Stella S Daskalopoulou
Apr 13, 2021·Biochemical Society Transactions·Georgia K Atkin-Smith
May 1, 2021·Cells·Jana Krystofova Mike, Donna Marie Ferriero
May 6, 2021·American Journal of Physiology. Gastrointestinal and Liver Physiology·Tian YuanBeverley Greenwood-Van Meerveld
May 7, 2021·Medicinal Research Reviews·Qing-Zhang TuoPeng Lei
Jun 26, 2021·Pharmacology & Therapeutics·Jody Tori O Cabrera, Ayako Makino
Aug 19, 2021·Apoptosis : an International Journal on Programmed Cell Death·Akvile HaeckelEyk Schellenberger
Dec 24, 2021·Journal of Drug Targeting·Joseph G Altin, Yabing Zhao

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Methods Mentioned

BETA
GTPases

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