Enhaced D2-type receptor activity facilitates the development of conditioned same-sex partner preference in male rats

Pharmacology, Biochemistry, and Behavior
Tamara Cibrian-LlanderalGenaro A Coria-Avila

Abstract

Animal models have shown that the neural bases of social attachment, sexual preference and pair bonds, depend on dopamine D2-type receptor and oxytocin activity. In addition, studies have demonstrated that cohabitation can shape partner preference via conditioning. Herein, we used rats to explore the development of learned same-sex partner preferences in adulthood as a result of cohabitation during enhanced D2 activity. Experimental Wistar males (N=20), received saline or the D2 agonist (quinpirole) and were allowed to cohabitate during 24 h, with a stimulus male partner that bore almond scent on the back as conditioned stimulus. This was repeated every 4 days, for a total of three trials. Four days later they were drug-free tested for partner preference between the scented male partner and a sexually receptive female. Sexual partner preference was analyzed by measuring frequency and latency for appetitive and consummatory sexual behaviors, as well as non-contact erections. Social preference was also analyzed by measuring the frequency and latency of visits, body contacts and time spent together. Results indicated that only quinpirole-treated males displayed sexual and social preference for the scented male over the sexually re...Continue Reading

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Citations

Nov 12, 2013·Neuroscience and Biobehavioral Reviews·Mirte BromPhilip Spinhoven
Feb 9, 2012·Archives of Sexual Behavior·Heather Hoffmann
Apr 29, 2014·Neuroscience and Biobehavioral Reviews·Genaro A Coria-AvilaJames G Pfaus
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Jul 28, 2015·Journal of Neuroendocrinology·C J W SmithA H Veenema
Feb 20, 2014·Physiology & Behavior·Tamara Cibrian-LlanderalGenaro A Coria-Avila
Jan 26, 2017·Behavioural Processes·Rodrigo Ramírez-RodríguezGenaro A Coria-Avila
Jul 13, 2017·Archives of Sexual Behavior·Heather Hoffmann
Nov 6, 2020·Hormones and Behavior·Nicole S Lee, Annaliese K Beery
Aug 28, 2018·Neurobiology of Learning and Memory·Meera E Modi, Mustafa Sahin

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