PMID: 108733Mar 22, 1979

Enhanced 5-hydroxytryptamine-mediated behavioural responses in rats following repeated electroconvulsive shock: relevance to the mechanism of the antidepressive effect of electroconvulsive therapy

D W CostainD G Grahame-Smith


Treatment of rats with one electroconvulsive shock (ECS) per day for 10 days enhanced the hyperactivity syndrome produced by administration of tranylcypromine (10 mg kg-1) and L-tryptophan (50 mg kg-1) given 24 h after the final shock. Similar enhancement was seen whether the shock was alternating sinusoidal or direct current (fractionated), whether it was given through unilaterally or bilaterally placed electrodes and whether or not a neuromuscular blocking agent (fazadinium) was used. Five shocks spread over 10 days or 8 shocks spread over 17 days were similarly effective, whilst 8 shocks in 1 day were ineffective. Therefore when ECS are given to rats in ways similar to those in which electroconvulsive therapy is given to patients with depression, enhancement of behavioural responses to increased 5-HT function is produced.


Feb 4, 1978·Lancet·D G Grahame-SmithD W Costain
Jun 1, 1977·The Journal of Nervous and Mental Disease·I S Turek, T E Hanlon
Aug 1, 1968·The British Journal of Psychiatry : the Journal of Mental Science·M ValentineD Dunne
Jan 1, 1958·The Journal of Mental Science·N P LANCASTERI FROST
Oct 1, 1959·The Journal of Mental Science·C P SEAGER


Jan 1, 1982·Journal of Psychiatric Research·D HealyB E Leonard
Oct 20, 1980·Life Sciences·S C Gerson, R J Baldessarini
Jan 13, 1986·Life Sciences·C A Stockmeier, K J Kellar
Jun 1, 1982·British Journal of Pharmacology·P J CowenD J Heal
Jan 1, 1986·Annals of the New York Academy of Sciences·W B Essman
Jul 2, 2014·Case Reports in Psychiatry·René KlysnerMaja Soon Hansen
Jun 20, 2008·Journal of Psychopharmacology·Ar GreenKcf Fone
Feb 1, 1992·The British Journal of Psychiatry : the Journal of Mental Science·B ShapiraA Calev
Oct 1, 1981·The British Journal of Psychiatry : the Journal of Mental Science·R E Kendell

Related Concepts

Behavior, Animal
Electroconvulsive Therapy
Electroconvulsive Shock
Rats, Laboratory

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