PMID: 7044453Jul 1, 1982

Enhanced acceptance of regenerating bone marrow of random bred newborn mice by random bred adult mice

Z Ben-IshayA Shushan


Regenerating bone marrow of newborn random bred Sabra mice (9-13 days old) was obtained by the administration of two consecutive i.p. injections of hydroxyurea (HU) (2 x 100 mg/kg body wt), three days prior to collection of the marrow cells. The bone marrow of HU-treated newborn mice was assayed for CFU-S, CFU-C and plasma-clot-diffusion-chamber (PCDC) progenitor cells. A fourfold content of CFU-S was found in the regenerating bone marrow compared with that of the control marrow, while the level of CFU-C and PCDC progenitor cells was the same in treated and untreated newborn mice. In lethally irradiated adult, random bred Sabra recipient mice, transfused with regenerating bone marrow from newborn mice, the initial survival rate was greater than in irradiated animals receiving normal newborn marrow (75% as against 50%); marrow repopulation, 10-14 days after transfusion, was also greater in the former than in the latter group of animals (1.5-2x10(6) nucleated cells per femur as compared with 08.-2x10(5)). The bone marrow of these groups of mice was assayed for CFU-S, CFU-C and PCDC progenitor cells; with a cell inoculum of 5 x 10(4) i.v., 10(5) in vitro and 5 x 10(4) per DC, respectively, pluripotent and committed stem cells were...Continue Reading


Mar 1, 1976·Scandinavian Journal of Haematology·N J RencriccaF Stohlman
Jan 1, 1979·Differentiation; Research in Biological Diversity·L G Lajtha
Jan 1, 1979·Nouvelle Revue Française D'hématologie·L G Lajtha
Oct 1, 1976·Proceedings of the Society for Experimental Biology and Medicine·A PorcelliniG Lucarelli
Mar 29, 1968·Annals of the New York Academy of Sciences·G LucarelliF Stohlman

Related Concepts

Protein S Deficiency
Colony-Forming Units, Hematopoietic
Spleen Colony-forming Unit
Entire Femur
Bone Marrow
Graft Survival
Blood Clot
Natural Regeneration

Related Feeds

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.