Enhanced activity of central adrenergic neurons in two-kidney, one clip hypertension in Sprague-Dawley rats

Neuroscience Letters
Ji-Yeon JungWon-Jae Kim

Abstract

The present study was aimed at investigating whether two-kidney, one clip (2K1C) hypertension is associated with an enhanced central adrenergic activity. Rats were made 2K1C hypertensive, and the expression of Fos-like immunoreactivity (FLI) and phenylethanalamine N-methyltransferase (PNMT)-immunoreactivity was determined in the brain areas related to the cardiovascular regulation. In 2K1C hypertension, the basal Fos-immunoreactivity was significantly increased in rostral ventrolateral medulla (RVLM), paraventricular nucleus (PVN), and supraoptic nucleus (SON). PNMT-immunoreactivities were noted in RVLM, but not in PVN or SON. Intracerebroventricular administration of angiotensin II (AII) markedly increased Fos-immunoreactivities, the degree of which was greater in hypertension. Furthermore, AII increased the ratio of PNMT-positive/Fos-positive neurons in RVLM in hypertension. It is suggested that the responsiveness to AII of the central adrenergic system is enhanced in 2K1C hypertension.

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Citations

Sep 9, 2008·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Maria Maliszewska-ScisloNoreen F Rossi
May 26, 2007·The Journal of Physiology·Patrick M Sonner, Javier E Stern
Aug 21, 2013·Journal of the Neurological Sciences·Song-Jie LiaoHai-Wei Huang
Feb 16, 2020·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Anthony SetiadiSong T Yao

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