PMID: 6108131Nov 14, 1980Paper

Enhanced albumin production by malignantly transformed hepatocytes during in vitro exposure to dimethylsulfoxide

Biochimica Et Biophysica Acta
P J Higgins, E Borenfreund

Abstract

The murine BW 1 and rat 32III 6/d tumor cell lines, derived from a spontaneous mouse hepatoma and a carcinogen-induced rat hepatocellular carcinoma, were used to investigate the effect of dimethylsulfoxide (DMSO) on liver cells in vitro. After a 4-day exposure to DMSO in final concentrations of 0.5 and 1.0%, BW 1 cell-associated albumin increased by 41.6 and 94.2%; extracellular albumin levels in these same cultures rose by 131.4 and 214.2%. Exposure of 32III 6/d cells to 2% DMSO produced increases in cell-associated and extra-cellular albumin concentrations of 67.8 and 188.7%, respectively. The lack of inducible gamma-glutamyl transpeptidase in BW 1 cells and its decrease in 32III 6/d cultures following DMSO treatment suggests that the DMSO-mediated enhancement of albumin production is not reflective of a random increase in the expression of cellular genes.

References

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Citations

Sep 1, 1993·In Vitro Cellular & Developmental Biology. Animal·T MitakaY Mochizuki
Apr 1, 1993·The International Journal of Biochemistry·M A Lea
Oct 19, 2006·Theory in Biosciences = Theorie in Den Biowissenschaften·Michael T Ghiselin
May 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·H C IsomJ Mummaw
Oct 27, 2016·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Vincent A van der MarkRuurdtje Hoekstra
Dec 15, 1986·International Journal of Cancer. Journal International Du Cancer·P J Higgins
Aug 15, 1988·International Journal of Cancer. Journal International Du Cancer·M P Ryan, P J Higgins
Aug 1, 1992·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·T MitakaY Mochizuki
Jan 1, 1984·Journal of Cellular Biochemistry·H S EarpJ Blaisdell
Jan 1, 1980·Annals of the New York Academy of Sciences·E BorenfreundA Bendich
Mar 1, 1991·Postgraduate Medical Journal·A Schattner
Oct 6, 2005·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Caroline AninatAndré Guillouzo

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