Enhanced alcohol degradation and hepatic protective effects of an Acetobacter Pasteurianus -derived product, CureZyme-ACE, in an acute intoxication rat model

Laboratory animal research
Eun-Jong JeonJungkee Kwon

Abstract

Excessive alcohol consumption induces acute intoxication and various hepatic diseases. In this study, we investigated the effect of the CureZyme-ACE (CA), Acetobacter Pasteurianus (AP)-derived product, in acute intoxication rats. The ethanol and acetaldehyde levels of serum were lower in rats treated with CA than those who only treated ethanol. The activities of alcohol dehydrogenase and acetaldehyde dehydrogenase also recovered faster in the CA group than only-ethanol group. The transaminase levels (AST, ALT) in the CA group were significantly lower than only-ethanol group. In addition, Hepatic histological analyses and stomach wall were demonstrated that the CA-treated group recovered faster than only-ethanol group. With regard to most characteristics, we found that CA had dose-dependent effects. At high concentrations of CA, there were no differences in the tested parameters compared to those of normal rats. These findings indicate that CA reduces the serum alcohol concentration and some of the hepatic damage caused by alcohol intoxication.

References

Aug 1, 1991·Alcoholism, Clinical and Experimental Research·C S Lieber
Dec 20, 2005·Drug and Alcohol Review·B J XuC K Sung
Sep 25, 2008·American Journal of Physiology. Endocrinology and Metabolism·Sofianos AndrikopoulosJoseph Proietto
Apr 29, 2014·Preventive Nutrition and Food Science·Ji Yeon SeoJong-Sang Kim
Dec 2, 2014·Journal of Clinical Medicine Research·Sensuke KonnoMuhammad Choudhury
Feb 10, 2018·Frontiers in Human Neuroscience·Kevin J VerdièreFrédéric Dehais

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Citations

Apr 28, 2021·Preparative Biochemistry & Biotechnology·Jeong-Muk LimByung-Taek Oh

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Methods Mentioned

BETA
Assay

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