PMID: 11924910Apr 2, 2002Paper

Enhanced anti-B-cell tumor effects with anti-CD20 superantibody

Journal of Immunotherapy
Yunfeng ZhaoHeinz Kohler

Abstract

The data presented here describe a novel approach to enhance the use of antibodies in diagnostic and therapeutic applications. Using a peptide copied from a rare self-binding (autophilic) antibody structure, the authors were able to convert by chemical cross-linking an anti-CD20 antibody to a self-binding (autophilic) structure. The autophilic antibody exhibited better binding to target tumor cells than the naked antibody. By the mechanism of hyper-cross-linking a B-cell receptor (CD20) on tumor cells, the rate of apoptosis is significantly increased, leading to strong inhibition of tumor growth in culture. The demonstration of enhanced binding and apoptosis targeting the CD20 B-cell marker serves as an example for developing second-generation therapeutic antibodies against non-Hodgkin lymphoma.

References

Apr 1, 1986·The Journal of Experimental Medicine·C Y Kang, H Kohler
Feb 14, 1997·Journal of Immunological Methods·G PavlinkovaH Kohler
Jul 8, 1997·Proceedings of the National Academy of Sciences of the United States of America·M A GhetieE S Vitetta
May 29, 2000·Applied Biochemistry and Biotechnology·H Kohler

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Citations

Aug 10, 2006·Cancer Immunology, Immunotherapy : CII·Yunfeng ZhaoSybille Muller
Sep 30, 2008·Cancer Immunology, Immunotherapy : CII·Heinz Kohler, Ann Jay Bryan
Dec 29, 2010·Cancer Immunology, Immunotherapy : CII·Ann Jay Bryan, Heinz Kohler
Mar 1, 2013·Immunotherapy·Heinz Kohler
Mar 11, 2005·Expert Opinion on Biological Therapy·Sybille MullerHeinz Kohler
Oct 19, 2010·Molecular Immunology·Tays HernándezRolando Pérez
Aug 23, 2005·Journal of Immunological Methods·Mike RussHeinz Kohler
May 13, 2008·Cancer Letters·Huili WangShuren Zhang
Oct 11, 2005·Drug Discovery Today·Yunfeng ZhaoHeinz Kohler
Sep 10, 2002·Journal of Immunotherapy·Yunfeng Zhao, Heinz Kohler

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