PMID: 11330477May 2, 2001Paper

Enhanced anti-cancer activities of some derivatives of titanocene dichloride

Journal of Inorganic Biochemistry
J R BoylesN Jain

Abstract

The compounds (eta5-C5H5)2TiCl2 (I), currently undergoing phase II trials, (eta5-C5H5)(eta5-C5H4CO2Me)TiCl2 (II) and C5H4CO2Me)2TiCl2 (III) are assessed for their efficacies against a small lung cancer cell line. It is found that the introduction of the electron withdrawing carbomethoxy group into the cyclopentadienyl rings increases the effectiveness of this class of drugs, such that III compares favorably with the well known cisplatin.

References

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Citations

May 16, 2006·Apoptosis : an International Journal on Programmed Cell Death·K O'ConnorR W G Watson
Nov 16, 2013·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Sze Koon LeeMd Akim Abdah
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Jun 15, 2007·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Li Ming GaoEnrique Meléndez
Sep 24, 2009·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Ramón HernándezEnrique Meléndez
Jan 13, 2015·Journal of Materials Science. Materials in Medicine·A ChrissanthopoulosE Dalas
Jun 13, 2006·Journal of Inorganic Biochemistry·Nigel SweeneyMatthias Tacke
Nov 27, 2004·The Journal of Pharmacy and Pharmacology·M Shamim HossainMamunur Rashid
Aug 8, 2007·Dalton Transactions : an International Journal of Inorganic Chemistry·P Manohari Abeysinghe, Margaret M Harding
Feb 22, 2008·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Ramón HernándezEnrique Meléndez
Jun 19, 2009·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Idainés FelicianoEnrique Meléndez
Jan 28, 2010·Chemistry : a European Journal·Timo A ImmelThomas Huhn
Mar 8, 2006·Anti-cancer Drugs·Iduna FichtnerMatthias Tacke
Oct 13, 2007·The Journal of Physical Chemistry. a·Galina V LoukovaVyatcheslav A Smirnov
Nov 26, 2010·European Journal of Medicinal Chemistry·Mariagrazia NapoliPasquale Longo

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