PMID: 591724Jan 1, 1977

Enhanced antibody responses to antigens presented on autologous erythrocytes

Journal of Immunological Methods
I A Ramshaw, C R Parish

Abstract

On a dose basis, antigen coupled to autologous red blood cells is 1,000--10,000-fold more efficient at inducing an antibody response than the soluble form. More than one antigen can be coupled simultaneously to the same red blood cells. Under these circumstances, prior immunization with one antigen enhances the antibody response to the other antigen, provided both antigens are coupled to the same red cell. Thus, the technique of coupling antigens to red blood cells is a means of producing high-titred antisera without the use of adjuvant and also represents a useful procedure for preparing composite antigens for probing cell-cell interaction in the immune response.

References

Jan 1, 1975·The Journal of Experimental Medicine·P H Lagrange, G B Mackaness
Mar 1, 1971·The Journal of Experimental Medicine·M N Pearson, S Raffel
Feb 18, 1956·Nature·F MILGROMS DUBISKI

Related Concepts

Metazoa
Antibody Formation
Antigens
Erythrocytes
Hemocyanin
Mice, Inbred CBA
Serum Albumin, Bovine
Mouse, Swiss

Related Feeds

Avian Influenza: Innate Immune Adjuvant

Adjuvants systems that are added to vaccines against avian influenza have be explored to enhance the innate immune system response against the virus. Here is the latest research on avian influenza and the innate immune adjuvant.

Avian Influenza: Innate Immune Adjuvant (ASM)

Adjuvants systems that are added to vaccines against avian influenza have be explored to enhance the innate immune system response against the virus. Here is the latest research on avian influenza and the innate immune adjuvant.