Enhanced anticancer effect of vincristine with methionine infusion after methionine-depleting total parenteral nutrition in tumor-bearing rats

Japanese Journal of Cancer Research : Gann
N GosekiM Endo

Abstract

Methionine-depleting total parenteral nutrition (Met(-) TPN), in which an amino acid solution devoid of L-methionine and L-cysteine is infused, is thought to reduce tumor cell growth through acting as a partial late S-G2 (i.e., late-S and G2 phases) blocker. The antitumor effect of vincristine (VCR), which acts on mitotic phase cells, was examined with methionine infusion immediately after Met(-) TPN in Yoshida sarcoma (YS)-bearing rats. Rats were given Met(-) TPN for 8 days immediately after inoculation with YS cells (days 0 to 8), which was followed by methionine-containing (Met(+)) regular TPN for 3 days (days 9-11) along with intraperitoneal administration of 0.05 mg/kg/day VCR. All rats were then fed solid food and water ad libitum until they died, with 0.1 mg/kg VCR administration on days 12 and 13. As controls, a Met(-) TPN only group, Met(+) TPN groups with and without VCR, and freely fed groups with and without VCR were studied. The progression of YS was markedly suppressed by Met(-) TPN with VCR. The median survival time in days was 25 days, significantly longer (P<0.001) (generalized Wilcoxon's tests) by 11 to 14 days than that of any of the other groups. In conclusion, VCR appears to have greater efficacy as an anti...Continue Reading

References

Apr 1, 1986·Journal of the National Cancer Institute·P H Stern, R M Hoffman
Mar 1, 1972·Archives of Surgery·E SteigerS J Dudrick
Dec 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·R M Hoffman, S J Jacobsen
Feb 6, 1965·Lancet·J D ALLANA D MOSS

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Citations

Oct 31, 2003·Cancer Treatment Reviews·E CellarierP Chollet
Aug 21, 2021·Naunyn-Schmiedeberg's Archives of Pharmacology·Yasmine A HassanAsser I Ghoneim

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