Enhanced antigen presenting and T cell functions during late-phase allergic responses in the lung.

Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology
M C LiuJ T Schroeder

Abstract

Allergic inflammation is a common feature of asthma and may contribute to both development and perpetuation of disease. The interaction of antigen-presenting cells (APC) with sensitized helper T lymphocytes (TC) producing Th2 cytokines may determine the inflammatory response. Recruitment of APC and TC to the lung during allergic responses has been demonstrated, but functional studies in humans have been limited. This study examined the function of APC and TC accumulating at sites of inflammation after segmental allergen challenge (SAC). Fifteen allergic patients underwent SAC, and cells from bronchoalveolar lavage (BAL) were collected after 24 hours. APC and TC from the blood and BAL were purified based on expression of the monocyte marker, CD14; the plasmacytoid dendritic cell (pDC) marker, BDCA4, identifying neuropilin-1 (NRP1); and the helper T cell marker, CD4. Functional activity was assessed using allergen-induced T cell proliferation. Flow cytometry identified cells expressing CD14 and NRP1. SAC resulted in a 12-fold increase in mononuclear cells having the morphologic appearance of blood monocytes. Most of these cells co-expressed CD14 and NRP1. After saline challenge, BAL mononuclear cells demonstrated little APC funct...Continue Reading

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Citations

Jul 30, 2020·Expert Review of Respiratory Medicine·Yang Xi, John W Upham
Dec 14, 2019·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·Graham RobertsJudith A Woodfolk

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