Enhanced Antimicrobial Activity and Structural Transitions of a Nanofibrillated Cellulose-Nisin Biocomposite Suspension

ACS Applied Materials & Interfaces
Ramon WeishauptGreta Faccio

Abstract

Resistance to antibiotics has posed a high demand for novel strategies to fight bacterial infections. Antimicrobial peptides (AMPs) are a promising alternative to conventional antibiotics. However, their poor solubility in water and sensitivity to degradation has limited their application. Here, we report the design of a smart, pH-responsive antimicrobial nanobiocomposite material based on the AMP nisin and 2,2,6,6-tetramethyl-1-piperidinyloxyl-oxidized nanofibrillated cellulose (TONFC). Morphological transformations of the nanoscale structure of nisin functionalized-TONFC fibrils were discovered at pH values between 5.8 and 8.0 using small-angle X-ray scattering. Complementary ζ potential measurements indicate that electrostatic attractions between the negatively charged TONFC surface and the positively charged nisin molecules are responsible for the integration of nisin. Modification of the pH level or increasing the ionic strength reduces the nisin binding capacity of TONFC. Biological evaluation studies using a bioluminescence-based reporter strain of Bacillus subtilis and a clinically relevant strain of Staphylococcus aureus indicated a significantly higher antimicrobial activity of the TONFC-nisin biocomposite compared to...Continue Reading

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Citations

Dec 3, 2020·Polymers·Kaja KupnikMaja Leitgeb
Dec 19, 2020·International Journal of Nanomedicine·Silvia TortorellaErica Locatelli
Jan 18, 2021·International Journal of Biological Macromolecules·Xiangxiang WangMingqiang Qiao
Jun 30, 2021·Biomacromolecules·Gary Chinga-CarrascoJoakim Håkansson

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