Enhanced antitumor effect of cisplatin in human NSCLC cells by tumor suppressor LKB1

Cancer Gene Therapy
W OuY Wei

Abstract

LKB1 is a novel candidate tumor suppressor gene in lung cancer. In this study, we evaluated the effect of cationic liposomes (LPs)-mediated LKB1 gene (LPs-pVAX-LKB1) on low-dose cisplatin (cis-diamminedichloroplatinum)-mediated antitumor activity in lung cancer, both in vitro and in vivo. Our study demonstrated that cationic LPs-mediated LKB1 gene therapy could sensitize the response of lung cancer cells to cisplatin, and significantly induce apoptosis and inhibit proliferation, invasion and metastasis, compared with control groups. Combined treatment with intratumoral administration of Lps-pVAX-LKB1 and intraperitoneal injection of low-dose cisplatin into subcutaneous A549 lung tumor xenograft resulted in significant (P<0.01) inhibition of tumor growth. Furthermore, combined treatment with intravenous injections of Lps-pVAX-LKB1 and intraperitoneal injection of low-dose cisplatin into mice bearing experimental A549 lung metastasis demonstrated significant (P<0.01) decrease in the number of lung metastatic tumor nodules. Mice life spans of combination treatment group were also dramatically prolonged, compared with controls. Further studies indicated that LKB1-enhancing cisplatin-mediated antitumor effects might be associated wi...Continue Reading

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Citations

Mar 25, 2014·Journal of Cancer Research and Clinical Oncology·Lingdong LiWen Zhu
Oct 29, 2014·The Journal of Cell Biology·Keefe T ChanJames E Bear
May 4, 2013·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Hua LiangCheng Xiang Yang
Feb 29, 2016·Acta Biochimica Et Biophysica Sinica·Detao WangYouxin Jin
Dec 9, 2016·Human Gene Therapy·Dolan SondhiRonald G Crystal
Jan 18, 2017·Journal of Controlled Release : Official Journal of the Controlled Release Society·Foyez MahmudYoungro Byun
Oct 28, 2019·Journal of Cancer Research and Clinical Oncology·Qianqian JiangWen Zhu
Feb 5, 2021·Advanced Drug Delivery Reviews·S G AntimisiarisS Mourtas

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