Enhanced antiviral activity of acyclovir loaded into nanoparticles

Methods in Enzymology
Roberta CavalliDavid Lembo

Abstract

The activity of antivirals can be enhanced by their incorporation in nanoparticulate delivery systems. Peculiar polymeric nanoparticles, based on a β-cyclodextrin-poly(4-acryloylmorpholine) monoconjugate (β-CD-PACM), are proposed as acyclovir carriers. The experimental procedure necessary to obtain the acyclovir-loaded nanoparticles using the solvent displacement preparation method will be described in this chapter. Fluorescent labeled nanoparticles are prepared using the same method for cellular trafficking studies. The biocompatibility assays necessary to obtain safe nanoparticles are reported. Section 4 of this chapter describes the assessment of the antiviral activity of the acyclovir-loaded nanoparticles.

Citations

Oct 18, 2013·BMC Complementary and Alternative Medicine·Manuela DonalisioDavid Lembo
Dec 18, 2012·Beilstein Journal of Organic Chemistry·Francesco TrottaRoberta Cavalli
Sep 2, 2016·Archives of Virology·Manik GhoshManuela Donalisio
Oct 17, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Hanadi SinokrotRafik Karaman
Apr 20, 2018·Phytotherapy Research : PTR·Marwa Mekni ToujaniManuela Donalisio
Jul 28, 2017·Therapeutic Advances in Infectious Disease·Lavanya SinghRaveen Parboosing
May 7, 2020·Advanced Pharmaceutical Bulletin·Dipak Dilip Gadade, Sanjay Sudhakar Pekamwar
Aug 2, 2020·International Journal of Pharmaceutics·Manuela DonalisioRoberta Cavalli
Nov 25, 2018·International Journal of Biological Macromolecules·Mehdi AlboofetilehGiancarlo Cravotto
Jun 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Giuseppe SquillaciAlessandra Morana
Aug 8, 2021·Nanomaterials·Syed Mohammed Basheeruddin AsdaqKatharigatta N Venugopala

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