Enhanced arachidonic acid and calcium metabolism in cholesteryl sulfate-enriched rat platelets

Journal of Lipid Mediators and Cell Signalling
D Blache


We previously found that cholesteryl sulfate (CS), a minor lipid constituent, is present in blood platelets and might influence platelet aggregation. In this study, we investigated whether CS modifies platelet arachidonic acid and calcium metabolism. In CS-loaded rat platelets, we found a potentiation of the arachidonate-induced aggregation, an increase in the thrombin-induced release of radiolabeled arachidonate preincorporated into platelet phospholipids and an increased formation of cyclooxygenase and lipoxygenase products. In addition, the calcium uptake in non-stimulated as well as in thrombin-stimulated CS-loaded platelets was enhanced. The above-mentioned effects were never observed with cholesterol, cholesteryl acetate, estrone and estrone sulfate. Although the precise determinants for the platelet CS concentration are not presently known, our findings might suggest a new role for CS as a modulator of the activity of these cells.


Jun 1, 1979·Biology of Reproduction·Y LegaultK D Roberts
Aug 11, 1978·Science·A A KandutschH J Heiniger
Jul 1, 1976·Biochimica Et Biophysica Acta·P Massini, E F Lüscher
Jul 1, 1977·The Journal of Clinical Investigation·T K BillsM J Silver
Jun 11, 1975·Biochimica Et Biophysica Acta·G LalumièreK D Roberts
Oct 1, 1991·Biochimie·P L Yeagle
Jul 1, 1987·Chemistry and Physics of Lipids·L L Smith
Apr 1, 1988·Thrombosis Research·D Blache, G Bontoux
Apr 1, 1985·Thrombosis Research·T ShimadaY Nagai
Feb 1, 1966·Biochimica Et Biophysica Acta·H W MoserJ C Orr
Nov 1, 1984·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·A C NestruckJ Davignon
Jul 1, 1981·The Journal of Clinical Endocrinology and Metabolism·E A Bergner, L J Shapiro
Dec 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·J LanglaisK D Roberts
Aug 1, 1981·Canadian Journal of Biochemistry·Y S HuangJ Davignon
Jan 3, 1980·The New England Journal of Medicine·M J StuartJ G White
Dec 7, 1995·Biochimica Et Biophysica Acta·D BlacheJ Davignon
May 1, 1966·Lipids·R O Mumma

❮ Previous
Next ❯


Dec 15, 2011·Current Diabetes Reports·E Albert Reece
Jun 12, 1998·Clinical Biochemistry·M PrzybylskaM Bryszewska
May 6, 2003·Journal of Lipid Research·Charles A Strott, Yuko Higashi
Dec 17, 2003·Circulation·Hidekatsu YanaiCharles A Strott
Apr 20, 2018·Journal of Proteome Research·Scott R HoganMichelle C LaPlaca

❮ Previous
Next ❯

Related Concepts

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.


Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.


Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.