Enhanced arachidonic acid and calcium metabolism in cholesteryl sulfate-enriched rat platelets

Journal of Lipid Mediators and Cell Signalling
D Blache

Abstract

We previously found that cholesteryl sulfate (CS), a minor lipid constituent, is present in blood platelets and might influence platelet aggregation. In this study, we investigated whether CS modifies platelet arachidonic acid and calcium metabolism. In CS-loaded rat platelets, we found a potentiation of the arachidonate-induced aggregation, an increase in the thrombin-induced release of radiolabeled arachidonate preincorporated into platelet phospholipids and an increased formation of cyclooxygenase and lipoxygenase products. In addition, the calcium uptake in non-stimulated as well as in thrombin-stimulated CS-loaded platelets was enhanced. The above-mentioned effects were never observed with cholesterol, cholesteryl acetate, estrone and estrone sulfate. Although the precise determinants for the platelet CS concentration are not presently known, our findings might suggest a new role for CS as a modulator of the activity of these cells.

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Citations

Dec 15, 2011·Current Diabetes Reports·E Albert Reece
Jun 12, 1998·Clinical Biochemistry·M PrzybylskaM Bryszewska
May 6, 2003·Journal of Lipid Research·Charles A Strott, Yuko Higashi
Dec 17, 2003·Circulation·Hidekatsu YanaiCharles A Strott
Apr 20, 2018·Journal of Proteome Research·Scott R HoganMichelle C LaPlaca

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