Enhanced attention in rhesus monkeys as a common factor for the cognitive effects of drugs with abuse potential

Psychopharmacology
John N BainJerry J Buccafusco

Abstract

One of the common neurochemical features of many drugs of abuse is their ability to directly or indirectly enhance dopaminergic activity in the brain, particularly within the ventral tegmental-nucleus accumbens pathway. Dopaminergic pathways in the frontal and limbic cortex also may be targets for these agents, where pharmacological effects could result in heightened attention and/or support self-administration behavior. The purpose of this study was to determine whether drugs from differing pharmacological classes that exhibit abuse potential would share the ability to counter distractability in the delayed matching task. Well trained mature macaques performed a computer-assisted delayed matching-to-sample task which included trials associated with three delay intervals and randomly interspersed task-relevant distractors. Drug regimens included four to five doses and subjects were tested no more than twice per week. All but one of the six compounds (tomoxetine), on average, increased task accuracy for either non-distractor or distractor trials. It was evident that for several compounds, doses required to improve accuracy for non-distractor trials were routinely greater than the doses required to improve accuracy for distractor...Continue Reading

References

Jan 1, 1977·British Journal of Clinical Pharmacology·R S Ehsanullah, P Turner
Dec 1, 1992·Synapse·J Day, H C Fibiger
Jan 1, 1991·Pharmacology, Biochemistry, and Behavior·G E Schulze, M G Paule
Dec 16, 1986·European Journal of Pharmacology·A ImperatoG Di Chiara
Jul 1, 1985·Journal of Neurochemistry·C MissaleI Hanbauer
May 1, 1995·Psychopharmacology·D M Warburton
Oct 3, 1994·European Journal of Pharmacology·J C DayH C Fibiger
Sep 1, 1993·Brain Research. Brain Research Reviews·T E Robinson, K C Berridge
Nov 1, 1995·Psychopharmacology·W A CarlezonR A Wise
Sep 25, 1997·Journal of Neuroscience Research·B Setlow
May 30, 1998·Cerebral Cortex·M A PrendergastJ J Buccafusco
May 20, 1998·The American Journal of Psychiatry·T SpencerL Seidman
Jul 23, 1999·Annals of the New York Academy of Sciences·J S de Olmos, L Heimer
Jul 23, 1999·Annals of the New York Academy of Sciences·G Di ChiaraE Carboni
Nov 24, 1999·Biological Psychiatry·J Biederman, T Spencer
Sep 7, 2000·Neurotoxicology and Teratology·P J BushnellD M Warburton
Dec 20, 2000·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·G F Koob, M Le Moal
Mar 7, 2001·Biological Psychiatry·A H Rezvani, E D Levin

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Citations

Sep 1, 2009·Integrative and Comparative Biology·Jennifer S ForbeyDeniz Tasdemir
May 21, 2011·Pharmacology, Biochemistry, and Behavior·L Cinnamon BidwellScott H Kollins
Jun 28, 2011·British Journal of Pharmacology·Leigh V PanlilioSteven R Goldberg
Dec 2, 2004·Peptides·Richard J Bodnar, Gad E Klein
Apr 24, 2015·Addiction Biology·Francis Joseph McClernonDana M Van Wert
Dec 11, 2014·Psychopharmacology·Jason SmucnyJason R Tregellas
Feb 27, 2020·Behavioural Pharmacology·Vanessa Minervini, Charles P France
Mar 7, 2015·Monash Bioethics Review·Mikael Dunlop, Julian Savulescu

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