Enhanced axonal metabolism during early natalizumab treatment in relapsing-remitting multiple sclerosis.

AJNR. American Journal of Neuroradiology
O T WiebengaJ J G Geurts

Abstract

The considerable clinical effect of natalizumab in patients with relapsing-remitting multiple sclerosis might be explained by its possible beneficial effect on axonal functioning. In this longitudinal study, the effect of natalizumab on absolute concentrations of total N-acetylaspartate, a marker for neuronal integrity, and other brain metabolites is investigated in patients with relapsing-remitting multiple sclerosis by using MR spectroscopic imaging. In this explorative observational study, 25 patients with relapsing-remitting multiple sclerosis initiating natalizumab treatment were included and scanned every 6 months for 18 months. Additionally 18 matched patients with relapsing-remitting multiple sclerosis continuing treatment with interferon-β or glatiramer acetate were included along with 12 healthy controls. Imaging included short TE 2D-MR spectroscopic imaging with absolute metabolite quantification of total N-acetylaspartate, creatine and phosphocreatine, choline-containing compounds, myo-inositol, and glutamate. Concentrations were determined for lesional white matter, normal-appearing white matter, and gray matter. At baseline in both patient groups, lower concentrations of total N-acetylaspartate and creatine and ph...Continue Reading

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Citations

Jun 30, 2016·Multiple Sclerosis : Clinical and Laboratory Research·Ethel CiampiXavier Montalban
Apr 14, 2017·Multiple Sclerosis : Clinical and Laboratory Research·Antoine M KlauserJeroen Jg Geurts
Jan 21, 2016·Therapeutic Advances in Neurological Disorders·Finn SellebjergDaniel Mikol
Feb 9, 2017·The Journal of Immunology : Official Journal of the American Association of Immunologists·Afsaneh Shirani, Olaf Stüve
Aug 5, 2017·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Kedar R Mahajan, Daniel Ontaneda
Sep 12, 2020·Nutritional Neuroscience·Sergej M Ostojic
Jun 18, 2020·International Journal of Molecular Sciences·Kim M A De Kleijn, Gerard J M Martens
Nov 14, 2020·Multiple Sclerosis : Clinical and Laboratory Research·Paolo PreziosaMaria A Rocca

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